Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 5/20 | 0.58 |
| ▸ | NAMPT | P43490 | 7/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13289097 | 0.94 | GSK3B (0.59) | GSK3BNAMPTCHEK1LMNATSHR | |
| SCHEMBL14545841 | 0.94 | GSK3B (0.56) | GSK3BNAMPTCHEK1LMNACYP3A4 | |
| SCHEMBL14307166 | 0.93 | GSK3B (0.56) | GSK3BNAMPTCHEK1LMNACYP3A4 | |
| SCHEMBL13288870 | 0.93 | GSK3B (0.56) | GSK3BNAMPTCHEK1 | |
| SCHEMBL14607249 | 0.92 | GSK3B (0.55) | GSK3BNAMPTCHEK1LMNACYP3A4 | |
| SCHEMBL14418840 | 0.91 | GSK3B (0.53) | GSK3BNAMPTCHEK1LMNACYP3A4 | |
| SCHEMBL12954082 | 0.91 | GSK3B (0.53) | GSK3BNAMPTCHEK1LMNACYP3A4 | |
| SCHEMBL14301590 | 0.91 | GSK3B (0.55) | GSK3BNAMPTCHEK1LMNA | |
| SCHEMBL13289101 | 0.91 | GSK3B (0.56) | GSK3BNAMPTCHEK1TSHR | |
| SCHEMBL12953926 | 0.90 | GSK3B (0.52) | GSK3BNAMPTCHEK1LMNACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720882-B1 | PYRAZOLOPYRIMIDINE-DERIVATIVES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORP (US) | 2011-01-05 | — | — | EP | disclosed |