Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALCRL | Q16602 | 18/20 | 0.77 |
| ▸ | CALCA | P06881 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2028302 | 0.92 | CALCRL (0.75) | CALCRLCALCA | |
| SCHEMBL12641419 | 0.92 | CALCRL (0.75) | CALCRLCALCA | |
| SCHEMBL12580814 | 0.92 | CALCRL (0.75) | CALCRLCALCA | |
| SCHEMBL12580811 | 0.87 | CALCRL (1.00) | CALCRLCALCA | |
| SCHEMBL2027541 | 0.87 | CALCRL (1.00) | CALCRLCALCA | |
| SCHEMBL12580832 | 0.79 | CALCRL (0.82) | CALCRLCALCA | |
| SCHEMBL12580840 | 0.76 | CALCRL (0.77) | CALCRLCALCA | |
| SCHEMBL12580830 | 0.76 | CALCRL (1.00) | CALCRLCALCA | |
| SCHEMBL12580837 | 0.76 | CALCRL (0.78) | CALCRLCALCA | |
| SCHEMBL12580843 | 0.75 | CALCRL (0.86) | CALCRLCALCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1951051-B1 | SPIROHYDANTOIN TRICYCLIC CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME (US) | 2012-10-03 | — | — | EP | disclosed |