Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 3/20 | 0.55 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.46 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.46 |
| ▸ | SGK1 | O00141 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 6/20 | 0.42 |
| ▸ | WDR77 | Q9BQA1 | 6/20 | 0.42 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | NOS3 | P29474 | 1/20 | 0.41 |
| ▸ | NOS1 | P29475 | 1/20 | 0.41 |
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.39 |
| ▸ | NMT1 | P30419 | 1/20 | 0.39 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | NEK2 | P51955 | 1/20 | 0.38 |
| ▸ | MAPK15 | Q8TD08 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20937942 | 0.88 | SGK1 (0.52) | CDK8SGK1PRMT5WDR77GSK3A | |
| SCHEMBL12965933 | 0.84 | CHEK1 (0.44) | CDK8FGFR1GSK3AGSK3BCHEK1 | |
| SCHEMBL12821617 | 0.80 | TNIK (0.53) | NMT1 | |
| SCHEMBL18371143 | 0.78 | CYP1A2 (0.33) | CDK8SGK1PRMT5WDR77CYP1A2 | |
| Hydrochloric Acid SCHEMBL18423416 | 0.77 | CYP1A2 (0.33) | CDK8SGK1PRMT5WDR77CYP1A2 | |
| SCHEMBL12821790 | 0.75 | AXL (0.60) | CDK8FGFR3SGK1FGFR1GSK3A | |
| SCHEMBL12821681 | 0.73 | CHEK1 (0.69) | FGFR1GSK3AGSK3BCHEK1KIT | |
| SCHEMBL12813739 | 0.73 | GSK3A (0.47) | CDK8GSK3AGSK3B | |
| SCHEMBL1585143 | 0.73 | SGK1 (0.54) | CDK8SGK1PRMT5WDR77GSK3A | |
| SCHEMBL12821647 | 0.73 | BTK (0.55) | CDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012135631-A1 | SUBSTITUTED 5-(PYRAZIN-2-YL)-1H-PYRAZOLO [3, 4-B] PYRIDINE AND PYRAZOLO [3, 4-B] PYRIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | ARRIEN PHARMAEUTICALS LLC (US) | 2012-10-04 | — | — | WO | disclosed |