Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 16/20 | 0.78 |
| ▸ | HSP90AB1 | P08238 | 16/20 | 0.78 |
| ▸ | KDR | P35968 | 2/20 | 0.37 |
| ▸ | POLQ | O75417 | 1/20 | 0.37 |
| ▸ | ALB | P02768 | 1/20 | 0.37 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.37 |
| ▸ | MAP1LC3A | Q9H492 | 1/20 | 0.37 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16702647 | 0.92 | HSP90AA1 (0.81) | HSP90AA1HSP90AB1KDRPOLQALB | |
| SCHEMBL18123498 | 0.92 | HSP90AA1 (0.82) | HSP90AA1HSP90AB1KDRPOLQALB | |
| SCHEMBL6936022 | 0.91 | HSP90AA1 (0.91) | HSP90AA1HSP90AB1KDRPOLQALB | |
| SCHEMBL6936597 | 0.91 | HSP90AA1 (0.78) | HSP90AA1HSP90AB1KDRPOLQALB | |
| SCHEMBL6935976 | 0.90 | HSP90AA1 (0.79) | HSP90AA1HSP90AB1KDRPOLQALB | |
| SCHEMBL16702631 | 0.89 | HSP90AA1 (0.88) | HSP90AA1HSP90AB1KDRPOLQALB | |
| SCHEMBL1607463 | 0.89 | HSP90AA1 (0.87) | HSP90AA1HSP90AB1KDRPOLQALB | |
| SCHEMBL16702307 | 0.88 | HSP90AA1 (0.81) | HSP90AA1HSP90AB1KDRPOLQALB | |
| SCHEMBL16710407 | 0.88 | HSP90AA1 (0.86) | HSP90AA1HSP90AB1KDRPOLQALB | |
| SCHEMBL1606209 | 0.88 | HSP90AA1 (1.00) | HSP90AA1HSP90AB1KDRPOLQALB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9120774-B2 | Novobiocin analogues having modified sugar moieties | UNIVERSITY OF KANSAS (US) | 2015-09-01 | — | — | US | disclosed |
| US-20120252745-A1 | NOVOBIOCIN ANALOGUES HAVING MODIFIED SUGAR MOIETIES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2012-10-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120252745-A1 | NOVOBIOCIN ANALOGUES HAVING MODIFIED SUGAR MOIETIES | HSP90AB1, HSP90AB2P, HSP90B1 | HSP90AA1 4/4885HSP90AB1 1/4885KDR 2366/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.