Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 11/20 | 1.00 |
| ▸ | DBF4 | Q9UBU7 | 10/20 | 1.00 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | LIMK1 | P53667 | 3/20 | 0.47 |
| ▸ | PLK4 | O00444 | 2/20 | 0.47 |
| ▸ | AURKA | O14965 | 2/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.47 |
| ▸ | PIM1 | P11309 | 2/20 | 0.47 |
| ▸ | PRKACA | P17612 | 2/20 | 0.47 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.47 |
| ▸ | CDK2 | P24941 | 2/20 | 0.47 |
| ▸ | MARK3 | P27448 | 2/20 | 0.47 |
| ▸ | FLT4 | P35916 | 2/20 | 0.47 |
| ▸ | KDR | P35968 | 2/20 | 0.47 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.47 |
| ▸ | GSK3A | P49840 | 2/20 | 0.47 |
| ▸ | STK3 | Q13188 | 2/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.47 |
| ▸ | MARK2 | Q7KZI7 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4893099 | 0.80 | CDC7 (0.69) | CDC7DBF4MAPTLIMK1PLK4 | |
| SCHEMBL4901082 | 0.78 | CDC7 (0.64) | CDC7DBF4MAPTLIMK1PLK4 | |
| SCHEMBL4903351 | 0.78 | CDC7 (0.64) | CDC7DBF4MAPTLIMK1PLK4 | |
| SCHEMBL4899965 | 0.73 | CDC7 (0.58) | CDC7DBF4MAPTLIMK1PLK4 | |
| SCHEMBL4901296 | 0.73 | CDC7 (0.56) | CDC7DBF4MAPTLIMK1PLK4 | |
| SCHEMBL4900523 | 0.73 | MAPT (0.60) | CDC7DBF4MAPTLIMK1PLK4 | |
| SCHEMBL4903159 | 0.67 | MAPT (1.00) | CDC7DBF4MAPTLIMK1PLK4 | |
| SCHEMBL4903289 | 0.66 | MAPT (0.74) | CDC7DBF4MAPTLIMK1PLK4 | |
| SCHEMBL4903009 | 0.65 | CDC7 (1.00) | CDC7DBF4MAPTLIMK1PLK4 | |
| SCHEMBL4893147 | 0.64 | MAPT (0.66) | CDC7DBF4MAPTLIMK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012131297-A1 | PYRIDO [3',2' :4,5] THIENO [3, 2-D] PYRIMIDIN- 4 - YLAMINE DERIVATIVES AND THEIR THERAPEUTICAL USE | BAELL JONATHAN BAYLDON (AU) | 2012-10-04 | — | — | WO | disclosed |