Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 5/20 | 0.61 |
| ▸ | CDC7 | O00311 | 6/20 | 0.54 |
| ▸ | DBF4 | Q9UBU7 | 6/20 | 0.54 |
| ▸ | CHUK | O15111 | 2/20 | 0.54 |
| ▸ | PLK4 | O00444 | 1/20 | 0.54 |
| ▸ | AURKA | O14965 | 1/20 | 0.54 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.54 |
| ▸ | FYN | P06241 | 1/20 | 0.54 |
| ▸ | PIM1 | P11309 | 1/20 | 0.54 |
| ▸ | PRKACA | P17612 | 1/20 | 0.54 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.54 |
| ▸ | CDK2 | P24941 | 1/20 | 0.54 |
| ▸ | MARK3 | P27448 | 1/20 | 0.54 |
| ▸ | AKT1 | P31749 | 1/20 | 0.54 |
| ▸ | FLT4 | P35916 | 1/20 | 0.54 |
| ▸ | KDR | P35968 | 1/20 | 0.54 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.54 |
| ▸ | GSK3A | P49840 | 1/20 | 0.54 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.54 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12969830 | 0.88 | CDC7 (0.58) | IKBKBCDC7DBF4CHUKPLK4 | |
| SCHEMBL12969828 | 0.83 | CDC7 (0.48) | IKBKBCDC7DBF4CHUKPLK4 | |
| SCHEMBL12969908 | 0.80 | KDM4E (0.63) | IKBKBCDC7DBF4CHUKPLK4 | |
| SCHEMBL12817782 | 0.79 | MAPK1 (0.64) | IKBKBCDC7DBF4CHUKPLK4 | |
| SCHEMBL12969835 | 0.77 | SMN1; SMN2 (0.67) | IKBKBCDC7DBF4CHUKPLK4 | |
| SCHEMBL12969827 | 0.77 | CDC7 (0.52) | IKBKBCDC7DBF4CHUKPLK4 | |
| SCHEMBL4892342 | 0.73 | IKBKB (0.61) | IKBKBCHUK | |
| SCHEMBL12969907 | 0.73 | CDC7 (0.53) | IKBKBCDC7DBF4CHUKPLK4 | |
| SCHEMBL4903009 | 0.71 | CDC7 (1.00) | IKBKBCDC7DBF4CHUKPLK4 | |
| SCHEMBL4903115 | 0.68 | IKBKB (0.60) | IKBKBCDC7DBF4CHUKPLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012131297-A1 | PYRIDO [3',2' :4,5] THIENO [3, 2-D] PYRIMIDIN- 4 - YLAMINE DERIVATIVES AND THEIR THERAPEUTICAL USE | BAELL JONATHAN BAYLDON (AU) | 2012-10-04 | — | — | WO | disclosed |