Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 10/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.61 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.53 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP4B1 | P13584 | 1/20 | 0.53 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.53 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.53 |
| ▸ | CYP2A7 | P20853 | 1/20 | 0.53 |
| ▸ | CYP3A7 | P24462 | 1/20 | 0.53 |
| ▸ | CYP2F1 | P24903 | 1/20 | 0.53 |
| ▸ | CYP2C18 | P33260 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1181273 | 0.89 | APP (1.00) | APPMAPK1ALDH1A1CYP3A4CYP1A1 | |
| SCHEMBL13446070 | 0.87 | APP (0.95) | APPMAPK1ALDH1A1CYP3A4CYP1A1 | |
| SCHEMBL14705443 | 0.87 | APP (0.95) | APPMAPK1ALDH1A1CYP3A4CYP1A1 | |
| SCHEMBL14705615 | 0.85 | APP (0.91) | APPMAPK1ALDH1A1CYP3A4CYP1A1 | |
| SCHEMBL9428523 | 0.84 | APP (0.73) | APPTDP1MAPK1ALDH1A1CYP3A4 | |
| SCHEMBL21427066 | 0.83 | APP (0.74) | APPTDP1MAPK1ALDH1A1CYP3A4 | |
| SCHEMBL21427063 | 0.83 | APP (0.74) | APPTDP1MAPK1ALDH1A1CYP3A4 | |
| SCHEMBL1926936 | 0.83 | TDP1 (0.84) | APPTDP1MAPK1ALDH1A1CYP3A4 | |
| SCHEMBL6751854 | 0.82 | APP (1.00) | APPTDP1ALDH1A1CYP3A4MAPT | |
| SCHEMBL12973226 | 0.82 | APP (0.83) | APPALDH1A1CYP3A4CYP1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7858072-B2 | Stilbene derivatives and their use for binding and imaging amyloid plaques | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2010-12-28 | — | — | US | disclosed |
| US-7858072-B2 | Stilbene derivatives and their use for binding and imaging amyloid plaques | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2010-12-28 | — | — | US | disclosed |