Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 18/20 | 0.74 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.74 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.74 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.74 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.74 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.74 |
| ▸ | ABCB4 | P21439 | 1/20 | 0.74 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.74 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.74 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.74 |
| ▸ | LPAR3 | Q9UBY5 | 12/20 | 0.64 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2761466 | 1.00 | LPAR1 (0.74) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL1325246 | 0.95 | LPAR1 (0.82) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL8006 | 0.95 | LPAR1 (0.82) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL8005 | 0.95 | LPAR1 (0.82) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL342934 | 0.93 | LPAR1 (0.78) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL342933 | 0.93 | LPAR1 (0.78) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL343676 | 0.92 | LPAR1 (0.77) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL343677 | 0.92 | LPAR1 (0.77) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL2761567 | 0.91 | LPAR1 (0.90) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL12973623 | 0.91 | LPAR1 (0.90) | LPAR1ABCC3ABCC4ABCB11CYP2C8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010141768-A2 | POLYCYCLIC ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2010-12-09 | — | — | WO | disclosed |