Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | PPM1B | O75688 | 1/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14652908 | 0.87 | NPC1 (0.47) | NPC1MAPK1HIF1AALDH1A1POLB | |
| SCHEMBL12993213 | 0.85 | NPC1 (0.45) | NPC1MAPK1HIF1AALDH1A1POLB | |
| SCHEMBL28422967 | 0.84 | NPC1 (0.44) | NPC1MAPK1HIF1AALDH1A1POLB | |
| SCHEMBL20756152 | 0.84 | NPC1 (0.44) | NPC1MAPK1HIF1AALDH1A1POLB | |
| SCHEMBL13066022 | 0.81 | NPC1 (0.46) | NPC1MAPK1HIF1AALDH1A1POLB | |
| SCHEMBL14644468 | 0.80 | NPC1 (0.45) | NPC1MAPK1ALDH1A1POLBGAA | |
| SCHEMBL17838017 | 0.79 | TDP1 (0.50) | NPC1MAPK1HIF1AALDH1A1POLB | |
| SCHEMBL17837383 | 0.79 | TDP1 (0.50) | NPC1MAPK1HIF1AALDH1A1POLB | |
| SCHEMBL13487241 | 0.78 | NPC1 (0.46) | NPC1MAPK1ALDH1A1POLBGAA | |
| SCHEMBL16188777 | 0.78 | NPC1 (0.46) | NPC1MAPK1ALDH1A1POLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7858761-B2 | 1-α-halo-2,2-difluoro-2-deoxy-D-ribofuranose derivatives and process for the preparation thereof | HANMI PHARM. CO., LTD (KR) | 2010-12-28 | — | — | US | disclosed |
| US-7799907-B2 | Method for the preparation of 2′-deoxy-2′,2′-difluorocytidine | HANMI PHARM. CO., LTD (KR) | 2010-09-21 | — | — | US | disclosed |