Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MARK3 | P27448 | 15/20 | 0.69 |
| ▸ | KDR | P35968 | 5/20 | 0.50 |
| ▸ | PRKAB1 | Q9Y478 | 5/20 | 0.50 |
| ▸ | BMPR1B | O00238 | 3/20 | 0.50 |
| ▸ | BMPR1A | P36894 | 3/20 | 0.50 |
| ▸ | ACVRL1 | P37023 | 3/20 | 0.50 |
| ▸ | TGFBR2 | P37173 | 3/20 | 0.50 |
| ▸ | ACVR1 | Q04771 | 3/20 | 0.50 |
| ▸ | BMPR2 | Q13873 | 3/20 | 0.50 |
| ▸ | ACVR1B | P36896 | 4/20 | 0.48 |
| ▸ | SGK1 | O00141 | 2/20 | 0.48 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.48 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.48 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.48 |
| ▸ | NUAK1 | O60285 | 2/20 | 0.48 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.48 |
| ▸ | JAK2 | O60674 | 2/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.48 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12997653 | 0.85 | MARK3 (0.68) | MARK3KDRPRKAB1ACVR1BSGK1 | |
| SCHEMBL12997777 | 0.85 | MARK3 (0.61) | MARK3KDRPRKAB1BMPR1BBMPR1A | |
| SCHEMBL12997652 | 0.84 | MARK3 (0.70) | MARK3KDRPRKAB1ACVR1BSGK1 | |
| SCHEMBL12997663 | 0.83 | MARK3 (0.77) | MARK3KDRPRKAB1ACVR1BSGK1 | |
| SCHEMBL12997649 | 0.83 | MARK3 (0.69) | MARK3KDRPRKAB1ACVR1BSGK1 | |
| SCHEMBL3767648 | 0.83 | MARK3 (0.73) | MARK3KDRPRKAB1ACVR1BSGK1 | |
| SCHEMBL12997736 | 0.82 | MARK3 (0.62) | MARK3KDRPRKAB1BMPR1BBMPR1A | |
| SCHEMBL3760412 | 0.82 | MARK3 (1.00) | MARK3KDRPRKAB1ACVR1BSGK1 | |
| SCHEMBL12997662 | 0.82 | MARK3 (0.75) | MARK3KDRPRKAB1ACVR1BSGK1 | |
| SCHEMBL12997737 | 0.82 | MARK3 (0.62) | MARK3KDRPRKAB1BMPR1BBMPR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8461162-B2 | Pyrazolo[1,5-a]pyrimidine derivatives | MERCK SHARP & DOHME CORP. (US) | 2013-06-11 | — | — | US | disclosed |
| US-8461162-B2 | Pyrazolo[1,5-a]pyrimidine derivatives | MERCK SHARP & DOHME CORP. (US) | 2013-06-11 | — | — | US | disclosed |
| US-20100305091-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES | MERCK SHARP & DOHME LLC | 2010-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100305091-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES | MAPT, TTBK1, TTBK2 | MARK3 12/4885KDR 3278/4885PRKAB1 450/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.