Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MARK3 | P27448 | 19/20 | 0.80 |
| ▸ | SGK1 | O00141 | 3/20 | 0.80 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.80 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.80 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.80 |
| ▸ | NUAK1 | O60285 | 3/20 | 0.80 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.80 |
| ▸ | JAK2 | O60674 | 3/20 | 0.80 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.80 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.80 |
| ▸ | RAF1 | P04049 | 3/20 | 0.80 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.80 |
| ▸ | LCK | P06239 | 3/20 | 0.80 |
| ▸ | CSF1R | P07333 | 3/20 | 0.80 |
| ▸ | MET | P08581 | 3/20 | 0.80 |
| ▸ | HCK | P08631 | 3/20 | 0.80 |
| ▸ | PIM1 | P11309 | 3/20 | 0.80 |
| ▸ | SRC | P12931 | 3/20 | 0.80 |
| ▸ | BRAF | P15056 | 3/20 | 0.80 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15006354 | 0.92 | MARK3 (0.73) | MARK3SGK1CHEK1MAPK13PDPK1 | |
| SCHEMBL12997806 | 0.92 | MARK3 (0.73) | MARK3SGK1CHEK1MAPK13PDPK1 | |
| SCHEMBL13053376 | 0.92 | MARK3 (0.73) | MARK3SGK1CHEK1MAPK13PDPK1 | |
| SCHEMBL15187426 | 0.90 | MARK3 (0.86) | MARK3SGK1CHEK1MAPK13PDPK1 | |
| SCHEMBL16418240 | 0.89 | MARK3 (1.00) | MARK3SGK1CHEK1MAPK13PDPK1 | |
| SCHEMBL15169515 | 0.89 | MARK3 (1.00) | MARK3SGK1CHEK1MAPK13PDPK1 | |
| SCHEMBL15168729 | 0.89 | MARK3 (1.00) | MARK3SGK1CHEK1MAPK13PDPK1 | |
| SCHEMBL12517750 | 0.87 | MARK3 (0.81) | MARK3SGK1CHEK1MAPK13PDPK1 | |
| SCHEMBL16418162 | 0.87 | MARK3 (0.81) | MARK3SGK1CHEK1MAPK13PDPK1 | |
| SCHEMBL15168796 | 0.87 | MARK3 (0.81) | MARK3SGK1CHEK1MAPK13PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117924102-A | Preparation method of microtubule affinity regulation kinase inhibitor intermediate | 成都伊诺达博医药科技有限公司 | 2024-04-26 | — | — | CN | disclosed |
| US-8461162-B2 | Pyrazolo[1,5-a]pyrimidine derivatives | MERCK SHARP & DOHME CORP. (US) | 2013-06-11 | — | — | US | disclosed |
| US-8461162-B2 | Pyrazolo[1,5-a]pyrimidine derivatives | MERCK SHARP & DOHME CORP. (US) | 2013-06-11 | — | — | US | disclosed |
| US-20100305091-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES | MERCK SHARP & DOHME LLC | 2010-12-02 | — | — | US | disclosed |
| US-20100305091-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES | MERCK SHARP & DOHME LLC | 2010-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100305091-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES | MAPT, TTBK1, TTBK2 | MARK3 12/4885SGK1 351/4885CHEK1 329/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.