Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 8/20 | 0.55 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.55 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.55 |
| ▸ | ABL1 | P00519 | 2/20 | 0.46 |
| ▸ | BCR | P11274 | 2/20 | 0.46 |
| ▸ | FLT3 | P36888 | 5/20 | 0.42 |
| ▸ | KDR | P35968 | 3/20 | 0.42 |
| ▸ | RET | P07949 | 3/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.42 |
| ▸ | PLK4 | O00444 | 2/20 | 0.42 |
| ▸ | FLT1 | P17948 | 2/20 | 0.42 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.42 |
| ▸ | STK25 | O00506 | 1/20 | 0.42 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | GAK | O14976 | 1/20 | 0.42 |
| ▸ | MUSK | O15146 | 1/20 | 0.42 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10295004 | 0.93 | AURKA (0.57) | AURKAAURKBRIPK1ABL1BCR | |
| SCHEMBL10294839 | 0.90 | AURKA (0.59) | AURKAAURKBRIPK1ABL1BCR | |
| SCHEMBL10294581 | 0.87 | AURKA (0.70) | AURKAAURKBRIPK1ABL1BCR | |
| SCHEMBL10294965 | 0.87 | AURKA (0.58) | AURKAAURKBRIPK1ABL1BCR | |
| SCHEMBL10294959 | 0.85 | AURKA (0.57) | AURKAAURKBRIPK1ABL1BCR | |
| SCHEMBL10294992 | 0.84 | AURKA (0.60) | AURKAAURKBRIPK1ABL1BCR | |
| SCHEMBL10294942 | 0.84 | AURKA (0.73) | AURKAAURKBRIPK1ABL1BCR | |
| SCHEMBL10294939 | 0.84 | AURKB (0.60) | AURKAAURKBRIPK1ABL1BCR | |
| SCHEMBL10294998 | 0.83 | AURKA (0.61) | AURKAAURKBRIPK1ABL1BCR | |
| SCHEMBL10294883 | 0.82 | AURKA (0.59) | AURKAAURKBRIPK1ABL1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010144359-A1 | TRIAZINE DERIVATIVES AND THEIR THERAPEUTICAL APPLICATIONS | ABRAXIS BIOSCIENCE, LLC (US) | 2010-12-16 | — | — | WO | disclosed |