Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 3/20 | 0.42 |
| ▸ | STS | P08842 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | UTS2R | Q9UKP6 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12713217 | 0.90 | CNR1 (0.42) | SMN1; SMN2TP53POLBCNR1STS | |
| SCHEMBL12713199 | 0.89 | SMN1; SMN2 (0.45) | SMN1; SMN2TP53POLBCNR1STS | |
| SCHEMBL12713213 | 0.89 | SMN1; SMN2 (0.47) | SMN1; SMN2TP53POLBCNR1STS | |
| SCHEMBL13948350 | 0.84 | SMN1; SMN2 (0.45) | SMN1; SMN2TP53POLBCNR1STS | |
| SCHEMBL12713201 | 0.82 | SMN1; SMN2 (0.46) | SMN1; SMN2TP53POLBCNR1STS | |
| SCHEMBL12713214 | 0.82 | SMN1; SMN2 (0.46) | SMN1; SMN2TP53POLBCNR1STS | |
| SCHEMBL13948343 | 0.82 | TP53 (0.44) | SMN1; SMN2TP53POLBCNR1STS | |
| SCHEMBL13940957 | 0.82 | TP53 (0.44) | SMN1; SMN2TP53POLBCNR1STS | |
| SCHEMBL12713212 | 0.81 | TP53 (0.47) | SMN1; SMN2TP53POLBCNR1STS | |
| SCHEMBL12713141 | 0.81 | SMN1; SMN2 (0.47) | SMN1; SMN2TP53POLBCNR1STS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2004604-B1 | SUBSTITUTED PHENYLPIPERIDINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR MODULATORS | SANTHERA PHARMACEUTICALS CH (CH) | 2010-12-01 | — | — | EP | disclosed |
| WO-2009015867-A1 | SUBSTITUTED ARYL OR HETEROARYLPIPERDINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR MODULATORS | SANTHERA PHARMACEUTICALS (SCHWEIZ) AG (CH) | 2009-02-05 | — | — | WO | disclosed |