Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.47 |
| ▸ | GRM5 | P41594 | 2/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.45 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12992020 | 0.88 | CLK1 (0.47) | DYRK1AGRM5PIK3CGPIK3CDPIK3CA | |
| SCHEMBL13004708 | 0.88 | DYRK1A (0.47) | DYRK1AGRM5PIK3CGPIK3CDPIK3CA | |
| SCHEMBL13004683 | 0.87 | PIK3CG (0.51) | SMN1; SMN2RAB9ANPC1DYRK1AGRM5 | |
| SCHEMBL12991135 | 0.86 | MAOB (0.50) | SMN1; SMN2RAB9ANPC1DYRK1AGRM5 | |
| SCHEMBL1702811 | 0.81 | GRM5 (0.62) | GRM5PIK3CGPIK3CA | |
| SCHEMBL13004673 | 0.81 | PIK3CG (0.65) | GRM5PIK3CGPIK3CDPIK3CAPIK3CB | |
| SCHEMBL13004691 | 0.80 | PIK3CG (0.49) | SMN1; SMN2RAB9ADYRK1APIK3CGKDM4E | |
| SCHEMBL13004689 | 0.79 | PIK3CG (0.46) | GRM5PIK3CGPIK3CDPIK3CAPIK3CB | |
| SCHEMBL12991813 | 0.78 | MAPT (0.53) | SMN1; SMN2RAB9ANPC1DYRK1APIK3CG | |
| SCHEMBL12991566 | 0.77 | ADORA1 (0.46) | RAB9ANPC1DYRK1APIK3CGLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8344153-B2 | Inhibitors of phosphatidylinositol 3-kinase | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-01-01 | — | — | US | disclosed |
| US-20100316605-A1 | INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-12-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100316605-A1 | INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASE | PIK3CA, PIK3CG, PIK3CD | SMN1; SMN2 1738/4885RAB9A 973/4885NPC1 1021/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.