Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN10A | Q9Y5Y9 | 3/20 | 0.34 |
| ▸ | TP53 | P04637 | 3/20 | 0.32 |
| ▸ | THRB | P10828 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | NAMPT | P43490 | 2/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.31 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.31 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.31 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.31 |
| ▸ | HTR1D | P28221 | 1/20 | 0.30 |
| ▸ | HTR1B | P28222 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10107980 | 0.89 | SCN10A (0.35) | SCN10ATP53NAMPTKCNH2 | |
| SCHEMBL10102643 | 0.87 | SCN10A (0.34) | SCN10ATP53MAPTKCNH2 | |
| SCHEMBL10102633 | 0.81 | RPS6KB2 (0.40) | SCN10ATP53MAPT | |
| SCHEMBL13005210 | 0.78 | AKT1 (0.39) | SCN10A | |
| SCHEMBL10102655 | 0.78 | PDE4B (0.37) | TP53MAPT | |
| SCHEMBL10102638 | 0.76 | GPBAR1 (0.42) | SCN10AKCNH2 | |
| SCHEMBL10107978 | 0.75 | SCN10A (0.33) | SCN10AKCNH2 | |
| SCHEMBL3386183 | 0.74 | PIK3CG (0.40) | SCN10AMAPT | |
| SCHEMBL13004730 | 0.71 | ERCC5 (0.35) | — | |
| SCHEMBL10102645 | 0.71 | CNR2 (0.38) | NAMPTKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1891011-B1 | TETRAHYDROQUINOLINES USED IN THE FORM OF MODULATORS OF MITOTIC MOTOR-PROTEINS EG5 | MERCK PATENT GMBH (DE) | 2010-12-08 | — | — | EP | disclosed |