Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 12/20 | 0.47 |
| ▸ | KIT | P10721 | 8/20 | 0.47 |
| ▸ | AXL | P30530 | 3/20 | 0.47 |
| ▸ | BACE1 | P56817 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | WNT3A | P56704 | 1/20 | 0.37 |
| ▸ | SORD | Q00796 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13007023 | 0.94 | FLT3 (0.56) | FLT3KITAXLBACE1AURKA | |
| SCHEMBL3387357 | 0.94 | FLT3 (0.56) | FLT3KITAXLBACE1AURKA | |
| SCHEMBL14275573 | 0.90 | FLT3 (0.56) | FLT3KITAXLBACE1JAK2 | |
| SCHEMBL13006581 | 0.88 | FLT3 (0.46) | FLT3KITAXLBACE1AURKA | |
| SCHEMBL14275722 | 0.88 | FLT3 (0.46) | FLT3KITAXLBACE1AURKA | |
| SCHEMBL14275718 | 0.88 | AXL (0.46) | FLT3KITAXLBACE1JAK2 | |
| SCHEMBL13006845 | 0.88 | FLT3 (0.45) | FLT3KITAXLBACE1AURKA | |
| SCHEMBL14275725 | 0.88 | FLT3 (0.45) | FLT3KITAXLBACE1AURKA | |
| SCHEMBL13006582 | 0.88 | FLT3 (0.45) | FLT3KITAXLBACE1WNT3A | |
| SCHEMBL14275709 | 0.88 | AXL (0.52) | FLT3KITAXLBACE1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1791830-B1 | DIAMINOTRIAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS | VERTEX PHARMA (US) | 2010-12-29 | — | — | EP | disclosed |
| US-7329652-B2 | Diaminotriazole compounds useful as protein kinase inhibitors | VERTEX PHARAMACEUTICALS INCORPORATED (US) | 2008-02-12 | — | — | US | disclosed |
| US-7329652-B2 | Diaminotriazole compounds useful as protein kinase inhibitors | VERTEX PHARAMACEUTICALS INCORPORATED (US) | 2008-02-12 | — | — | US | disclosed |