Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 13/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 13/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 12/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 12/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 12/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 12/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 12/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 12/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 12/20 | 0.49 |
| ▸ | HDAC9 | Q9UKV0 | 12/20 | 0.49 |
| ▸ | HDAC5 | Q9UQL6 | 12/20 | 0.49 |
| ▸ | KDM1A | O60341 | 3/20 | 0.47 |
| ▸ | DGAT2 | Q96PD7 | 3/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | ANPEP | P15144 | 1/20 | 0.42 |
| ▸ | LAP3 | P28838 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13061239 | 0.86 | HDAC6 (0.55) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL13007264 | 0.86 | HDAC6 (0.49) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL8194315 | 0.84 | HDAC3 (0.59) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL13061216 | 0.84 | HDAC3 (0.59) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL8204490 | 0.84 | HDAC6 (0.37) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL3772993 | 0.84 | HDAC1 (0.45) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL3773002 | 0.84 | HDAC1 (0.45) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL15906826 | 0.82 | HDAC6 (0.44) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL13007259 | 0.82 | HDAC6 (0.46) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL13061427 | 0.80 | HDAC6 (0.55) | HDAC1HDAC6HDAC3HDAC4HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8962825-B2 | Hydroxamates as inhibitors of histone deacetylase | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2015-02-24 | — | — | US | disclosed |
| US-8962825-B2 | Hydroxamates as inhibitors of histone deacetylase | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2015-02-24 | — | — | US | disclosed |
| US-20100317678-A1 | HYDROXAMATES AS INHIBITORS OF HISTONE DEACETYLASE | CHROMA THERAPEUTICS LTD. (GB) | 2010-12-16 | — | — | US | disclosed |
| US-20100317678-A1 | HYDROXAMATES AS INHIBITORS OF HISTONE DEACETYLASE | CHROMA THERAPEUTICS LTD. (GB) | 2010-12-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100317678-A1 | HYDROXAMATES AS INHIBITORS OF HISTONE DEACETYLASE | H1-2, HDAC1, H1-0 | HDAC1 2/4885HDAC6 23/4885HDAC3 13/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.