Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 20/20 | 0.64 |
| ▸ | HSPB1 | P04792 | 2/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.49 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.49 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3408656 | 0.92 | MAPK14 (0.75) | MAPK14HSPB1CYP2C9MAPK13MAPK12 | |
| SCHEMBL3404864 | 0.80 | MAPK14 (0.87) | MAPK14HSPB1CYP2C9MAPK11 | |
| Gw743024X SCHEMBL4817886 | 0.78 | MAPK14 (1.00) | MAPK14HSPB1 | |
| SCHEMBL3402871 | 0.78 | MAPK14 (0.75) | MAPK14HSPB1CYP2C9MAPK13MAPK12 | |
| SCHEMBL3406048 | 0.76 | MAPK14 (0.80) | MAPK14HSPB1CYP2C9MAPK13MAPK12 | |
| SCHEMBL3405640 | 0.75 | MAPK14 (0.68) | MAPK14HSPB1CYP2C9MAPK13MAPK12 | |
| SCHEMBL3405481 | 0.75 | MAPK14 (1.00) | MAPK14HSPB1CYP2C9MAPK11 | |
| SCHEMBL14365176 | 0.75 | MAPK14 (0.71) | MAPK14HSPB1CYP2C9MAPK11 | |
| SCHEMBL14403203 | 0.75 | MAPK14 (0.62) | MAPK14CYP2C9MAPK11 | |
| SCHEMBL3409280 | 0.73 | P4HTM (0.53) | MAPK14HSPB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2258687-A1 | Nicotinamide derivates useful as P38 inhibitors | Glaxosmithkline LLC (US) | 2010-12-08 | — | — | EP | disclosed |