⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13014751 | 0.85 | FABP1 (0.58) | — | |
| SCHEMBL13014758 | 0.85 | — | — | |
| SCHEMBL13014782 | 0.84 | — | — | |
| SCHEMBL13014773 | 0.83 | — | — | |
| SCHEMBL2274832 | 0.83 | — | — | |
| SCHEMBL13014761 | 0.82 | — | — | |
| SCHEMBL13014742 | 0.82 | — | — | |
| SCHEMBL13014745 | 0.82 | — | — | |
| Hydrochloric Acid SCHEMBL2271152 | 0.82 | — | — | |
| SCHEMBL13014749 | 0.81 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170057932-A1 | BIPHENYL AND PHENYL-PYRIDINE AMIDES AS P2X3 AND P2X2/3 ANTAGONISTS | ROCHE PALO ALTO LLC (US) | 2017-03-02 | — | — | US | disclosed |
| US-9505726-B2 | Substituted biphenyl amides as P2X3 and P2X2/3 antagonists | ROCHE PALO ALTO LLC (US) | 2016-11-29 | — | — | US | disclosed |
| US-20150080408-A1 | PYRIDINYL AMIDES AS P2X3 AND P2X2/3 INHIBITORS | ROCHE PALO ALTO LLC (US) | 2015-03-19 | — | — | US | disclosed |
| US-8895589-B2 | Pyridinyl amides as P2X3 and P2X2/3 inhibitors | ROCHE PALO ALTO LLC (US) | 2014-11-25 | — | — | US | disclosed |
| US-20130165443-A1 | BIPHENYL AND PHENYL-PYRIDINE AMIDES AS P2X3 AND P2X2/3 ANTAGONISTS | BROKA CHRIS ALLEN (US) | 2013-06-27 | — | — | US | disclosed |
| US-8283383-B2 | Biphenyl amides as P2X3 and P2X2/3 antagonists | ROCHE PALO ALTO LLC (US) | 2012-10-09 | — | — | US | disclosed |
| US-8283383-B2 | Biphenyl amides as P2X3 and P2X2/3 antagonists | ROCHE PALO ALTO LLC (US) | 2012-10-09 | — | — | US | disclosed |
| WO-2010149578-A2 | NOVEL BIPHENYL AND PHENYL-PYRIDINE AMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-12-29 | — | — | WO | disclosed |
| US-20100324056-A1 | BIPHENYL AND PHENYL-PYRIDINE AMIDES AS P2X3 AND P2X2/3 ANTAGONISTS | BROKA CHRIS ALLEN | 2010-12-23 | — | — | US | disclosed |
| US-20100324056-A1 | BIPHENYL AND PHENYL-PYRIDINE AMIDES AS P2X3 AND P2X2/3 ANTAGONISTS | BROKA CHRIS ALLEN | 2010-12-23 | — | — | US | disclosed |