Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 8/20 | 0.36 |
| ▸ | PDE4A | P27815 | 7/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL128620 | 0.80 | PRMT5 (0.31) | PDE4DPDE4APDE4BPDE4CPDE3B | |
| SCHEMBL128245 | 0.79 | GRIN2B (0.33) | PDE4DPDE4APDE4BPDE4CPDE3B | |
| SCHEMBL129930 | 0.79 | PDE4D (0.32) | PDE4DPDE4APDE4BPDE4CPDE3B | |
| SCHEMBL4371937 | 0.79 | PDE4D (0.35) | PDE4DPDE4APDE4BPDE4CPDE3B | |
| SCHEMBL129045 | 0.79 | PDE4D (0.33) | PDE4DPDE4APDE4BPDE4CPDE3B | |
| SCHEMBL125740 | 0.78 | PDE4D (0.33) | PDE4DPDE4APDE4BPDE4CPDE3B | |
| SCHEMBL127871 | 0.77 | PDE4D (0.33) | PDE4DPDE4APDE4BPDE4CMAPT | |
| SCHEMBL129318 | 0.77 | GRIN2B (0.32) | PDE4DPDE4APDE4BPDE4CKCNH2 | |
| SCHEMBL129545 | 0.77 | KCNH2 (0.30) | PDE4DPDE4APDE4BPDE4CPDE3B | |
| SCHEMBL128908 | 0.77 | PDE4A (0.35) | PDE4DPDE4APDE4BPDE4CCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1982986-B1 | PYRROLOPYRIDAZINONE COMPOUND AS PDE4 INHIBITOR | UBE INDUSTRIES (JP) | 2012-03-07 | — | — | EP | claimed |