Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 15/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.48 |
| ▸ | IGF1R | P08069 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | AKT1 | P31749 | 1/20 | 0.48 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.48 |
| ▸ | NEK2 | P51955 | 1/20 | 0.48 |
| ▸ | STK3 | Q13188 | 1/20 | 0.48 |
| ▸ | CAMK4 | Q16566 | 1/20 | 0.48 |
| ▸ | TSSK2 | Q96PF2 | 1/20 | 0.48 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.48 |
| ▸ | PIM1 | P11309 | 2/20 | 0.45 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13015474 | 0.91 | CHEK1 (0.56) | CHEK1HDAC2JAK2ROCK2IGF1R | |
| SCHEMBL13015527 | 0.90 | CHEK1 (0.58) | CHEK1HDAC2JAK2ROCK2IGF1R | |
| SCHEMBL13015564 | 0.90 | CHEK1 (0.51) | CHEK1HDAC2JAK2ROCK2IGF1R | |
| SCHEMBL13015591 | 0.88 | CHEK1 (0.51) | CHEK1HDAC2JAK2ROCK2IGF1R | |
| SCHEMBL13015531 | 0.88 | CHEK1 (0.58) | CHEK1HDAC2JAK2ROCK2IGF1R | |
| SCHEMBL13015592 | 0.88 | CHEK1 (0.45) | CHEK1HDAC2JAK2ROCK2IGF1R | |
| SCHEMBL13015597 | 0.87 | CHEK1 (0.46) | CHEK1HDAC2JAK2ROCK2IGF1R | |
| SCHEMBL13015551 | 0.86 | CHEK1 (0.50) | CHEK1HDAC2JAK2ROCK2IGF1R | |
| SCHEMBL13015537 | 0.86 | CHEK1 (0.51) | CHEK1HDAC2JAK2ROCK2IGF1R | |
| SCHEMBL13015557 | 0.85 | CHEK1 (0.48) | CHEK1HDAC2JAK2ROCK2IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8476278-B2 | Thiazole Derivatives as protein kinase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2013-07-02 | — | — | US | disclosed |
| US-8476278-B2 | Thiazole Derivatives as protein kinase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2013-07-02 | — | — | US | disclosed |
| US-20100331313-A1 | Thiazole Derivatives as Protein Kinase Inhibitors | SCHERING CORPORATION | 2010-12-30 | — | — | US | disclosed |
| US-20100331313-A1 | Thiazole Derivatives as Protein Kinase Inhibitors | SCHERING CORPORATION | 2010-12-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100331313-A1 | Thiazole Derivatives as Protein Kinase Inhibitors | DAPK2, DAPK1, JAK1 | CHEK1 265/4885HDAC2 482/4885JAK2 31/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.