Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3R1 | P27986 | 12/20 | 0.83 |
| ▸ | PIK3CA | P42336 | 12/20 | 0.83 |
| ▸ | MTOR | P42345 | 8/20 | 0.83 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.83 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.83 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.83 |
| ▸ | PIK3C2B | O00750 | 2/20 | 0.83 |
| ▸ | PRKDC | P78527 | 2/20 | 0.83 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.83 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.83 |
| ▸ | PIK3R5 | Q8WYR1 | 2/20 | 0.83 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.83 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.74 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.74 |
| ▸ | MAPKAP1 | Q9BPZ7 | 1/20 | 0.74 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Buparlisib SCHEMBL29387968 | 0.91 | MTOR (1.00) | PIK3R1PIK3CAMTORPIK3CGPIK3CD | |
| Buparlisib SCHEMBL29351351 | 0.91 | MTOR (1.00) | PIK3R1PIK3CAMTORPIK3CGPIK3CD | |
| Buparlisib SCHEMBL29350945 | 0.91 | MTOR (1.00) | PIK3R1PIK3CAMTORPIK3CGPIK3CD | |
| SCHEMBL13016692 | 0.91 | PIK3R1 (0.80) | PIK3R1PIK3CAMTORPIK3CGPIK3CD | |
| Buparlisib SCHEMBL146956 | 0.91 | MTOR (1.00) | PIK3R1PIK3CAMTORPIK3CGPIK3CD | |
| SCHEMBL2814525 | 0.90 | PIK3R1 (0.78) | PIK3R1PIK3CAMTORPIK3CGPIK3CD | |
| Buparlisib SCHEMBL143412 | 0.90 | MTOR (0.98) | PIK3R1PIK3CAMTORPIK3CGPIK3CD | |
| Buparlisib SCHEMBL18528952 | 0.90 | MTOR (0.98) | PIK3R1PIK3CAMTORPIK3CGPIK3CD | |
| Buparlisib SCHEMBL896966 | 0.90 | MTOR (0.98) | PIK3R1PIK3CAMTORPIK3CGPIK3CD | |
| Buparlisib SCHEMBL29493083 | 0.90 | MTOR (0.98) | PIK3R1PIK3CAMTORPIK3CGPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2261223-B1 | Pyrimidine derivatives used as pi-3 kinase inhibitors | NOVARTIS AG (CH) | 2013-06-12 | — | — | EP | disclosed |
| EP-2261223-A1 | Pyrimidine derivatives used as pi-3 kinase inhibitors | Novartis AG (CH) | 2010-12-15 | — | — | EP | disclosed |
| EP-1984350-B1 | PYRIMIDINE DERIVATIVES USED AS PI-3 KINASE INHIBITORS | NOVARTIS AG (CH) | 2010-08-18 | — | — | EP | disclosed |
| WO-2007084786-A1 | PYRIMIDINE DERIVATIVES USED AS PI-3 KINASE INHIBITORS | NOVARTIS AG (CH) | 2007-07-26 | — | — | WO | disclosed |