Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 5/20 | 0.63 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.53 |
| ▸ | JAK3 | P52333 | 5/20 | 0.52 |
| ▸ | JAK2 | O60674 | 4/20 | 0.52 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.52 |
| ▸ | TYK2 | P29597 | 1/20 | 0.50 |
| ▸ | NCF1 | P14598 | 1/20 | 0.49 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.47 |
| ▸ | NOS1 | P29475 | 1/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.45 |
| ▸ | USP7 | Q93009 | 1/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1422646 | 0.88 | JAK1 (0.72) | JAK1NUDT1JAK3JAK2PTK2 | |
| SCHEMBL219962 | 0.78 | JAK1 (1.00) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL18485205 | 0.78 | JAK1 (0.80) | JAK1JAK3JAK2PTK2TYK2 | |
| SCHEMBL15654121 | 0.78 | JAK1 (0.64) | JAK1NUDT1JAK3JAK2PTK2 | |
| SCHEMBL15654035 | 0.77 | JAK1 (0.77) | JAK1NUDT1JAK3JAK2PTK2 | |
| SCHEMBL15654616 | 0.76 | JAK1 (0.71) | JAK1NUDT1JAK3JAK2TYK2 | |
| SCHEMBL21530929 | 0.75 | JAK2 (0.63) | JAK1JAK3JAK2PTK2TYK2 | |
| SCHEMBL21530947 | 0.75 | JAK2 (0.63) | JAK1JAK3JAK2PTK2TYK2 | |
| SCHEMBL21530991 | 0.74 | JAK2 (0.62) | JAK1JAK3JAK2PTK2TYK2 | |
| SCHEMBL22590377 | 0.74 | JAK2 (0.62) | JAK1JAK3JAK2PTK2TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010149769-A1 | 5-PHENYL-[1,2,4 ]TRIAZOLO[1,5-A]PYRIDIN-2-YL CARBOXAMIDES AS JAK INHIBITORS | GALAPAGOS NV (BE) | 2010-12-29 | — | — | WO | disclosed |