Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13433 | 1.00 | KDM4E (0.45) | KDM4ELMNARAB9AHRH3ALDH1A1 | |
| SCHEMBL12449639 | 1.00 | KDM4E (0.45) | KDM4ELMNARAB9AHRH3ALDH1A1 | |
| SCHEMBL17277609 | 0.95 | HRH3 (0.45) | KDM4EHRH3KEAP1SMN1; SMN2 | |
| SCHEMBL12449699 | 0.88 | KDM4E (0.45) | KDM4ELMNARAB9AHRH3ALDH1A1 | |
| SCHEMBL1430617 | 0.88 | KDM4E (0.45) | KDM4ELMNARAB9AHRH3ALDH1A1 | |
| SCHEMBL12995 | 0.88 | KDM4E (0.45) | KDM4ELMNARAB9AHRH3ALDH1A1 | |
| SCHEMBL12942 | 0.88 | KDM4E (0.50) | KDM4ELMNAHRH3ALDH1A1MAPT | |
| SCHEMBL12449677 | 0.88 | KDM4E (0.50) | KDM4ELMNAHRH3ALDH1A1MAPT | |
| SCHEMBL12666 | 0.86 | KDM4E (0.49) | KDM4ELMNAHRH3ALDH1A1MAPT | |
| SCHEMBL11907 | 0.86 | KDM4E (0.49) | KDM4ELMNAHRH3ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011058149-A1 | TRICYCLIC PYRAZOL AMINE DERIVATIVES | MERCK SERONO S.A. (CH) | 2011-05-19 | — | — | WO | disclosed |