⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12482464 | 0.61 | — | — | |
| SCHEMBL2316165 | 0.60 | — | — | |
| SCHEMBL74000 | 0.60 | — | — | |
| SCHEMBL4622712 | 0.58 | — | — | |
| Methane SCHEMBL11216534 | 0.58 | — | — | |
| SCHEMBL10283719 | 0.56 | — | — | |
| SCHEMBL9368122 | 0.55 | — | — | |
| SCHEMBL566732 | 0.55 | — | — | |
| SCHEMBL15238118 | 0.54 | — | — | |
| SCHEMBL8805461 | 0.54 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2229385-A2 | BENZIMIDAZOLEDIHYDROTHIADIAZINONE DERIVATIVES AS FRUCTOSE-1,6-BISPHOSPHATASE INHIBITORS, AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME | Merck Patent GmbH (DE) | 2010-09-22 | — | — | EP | claimed |
| WO-2009062576-A2 | BENZIMIDAZOLEDIHYDROTHIADIAZINONE DERIVATIVES AS FRUCTOSE-1,6-BISPHOSPHATASE INHIBITORS, AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME | MERCK PATENT GMBH (DE) | 2009-05-22 | — | — | WO | claimed |
| EP-0399196-A1 | Diazine derivatives, process for their preparation, and medicaments containing these compounds | HEUMANN PHARMA GMBH & CO (DE) | 1990-11-28 | — | — | EP | claimed |
| US-8877751-B2 | Benzothiazolone derivatives | MERCK PATENT GMBH (DE) | 2014-11-04 | — | — | US | disclosed |
| US-8431572-B2 | 2-oxo-3-benzylbenzoxazol-2-one derivatives and related compounds as met kinase inhibitors for the treatment of tumours | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2013-04-30 | — | — | US | disclosed |
| CN-101679401-B | 2-oxo-3-benzyl-benzoxazol-2-one derivatives and related compounds as MET kinase inhibitors for the treatment of tumors | MERCK PATENT GMBH | 2012-12-12 | — | — | CN | disclosed |
| US-8071593-B2 | 2-oxo-3-benzylbenzoxazol-2-one derivatives and related compounds as Met kinase inhibitors for the treatment of tumours | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2011-12-06 | — | — | US | disclosed |
| US-20110269756-A1 | BENZOTHIAZOLONE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2011-11-03 | — | — | US | disclosed |
| US-20110263596-A1 | 2-OXO-3-BENZYLBENZOXAZOL-2-ONE DERIVATIVES AND RELATED COMPOUNDS AS MET KINASE INHIBITORS FOR THE TREATMENT OF TUMOURS | SCHADT OLIVER | 2011-10-27 | — | — | US | disclosed |
| EP-1963295-B1 | 3, 6-DIHYDRO-2-OXO-6H-(1,3,4)THIADIAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2011-08-03 | — | — | EP | disclosed |
| US-20100280030-A1 | 2-OXO-3-BENZYLBENZOXAZOL-2-ONE DERIVATIVES AND RELATED COMPOUNDS AS MET KINASE INHIBITORS FOR THE TREATMENT OF TUMOURS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2010-11-04 | — | — | US | disclosed |
| CN-101312958-A | 3, 6-dihydro-2-oxo-6H-1, 3, 4-thiadiazine derivatives | MERCK PATENT GMBH (DE) | 2008-11-26 | — | — | CN | disclosed |
| CN-101312958-A | 3, 6-dihydro-2-oxo-6H-1, 3, 4-thiadiazine derivatives | MERCK PATENT GMBH (DE) | 2008-11-26 | — | — | CN | disclosed |
| EP-1963295-A1 | 3, 6-DIHYDRO-2-OXO-6H-(1,3,4)THIADIAZINE DERIVATIVES | Merck Patent GmbH (DE) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007057093-A1 | 3, 6-DIHYDRO-2-OXO-6H-(1,3,4)THIADIAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2007-05-24 | — | — | WO | disclosed |
| US-5728698-A | AGRICULTURAL USE, RICE, WHEAT | ROHM AND HAAS COMPANY (US) | 1998-03-17 | — | — | US | disclosed |
| US-5574033-A | Heterocyclic compound and cardiotonic agent containing the same as effective component | ZENYAKU KOGYO KABUSHIKI KAISHA (JP) | 1996-11-12 | — | — | US | disclosed |
| US-5108998-A | CARDIOTONIC THIADIAZINE DERIVATIVES | HEUMANN PHARMA GMBH & CO. (DE) | 1992-04-28 | — | — | US | disclosed |
| EP-0399196-A1 | Diazine derivatives, process for their preparation, and medicaments containing these compounds | HEUMANN PHARMA GMBH & CO (DE) | 1990-11-28 | — | — | EP | disclosed |
| US-4916128-A | Thiadiazinones | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1990-04-10 | — | — | US | disclosed |