Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTRL | P40313 | 6/20 | 0.65 |
| ▸ | TMPRSS11D | O60235 | 4/20 | 0.65 |
| ▸ | PSMB5 | P28074 | 12/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.64 |
| ▸ | CYP3A5 | P20815 | 2/20 | 0.64 |
| ▸ | CYP3A7 | P24462 | 2/20 | 0.64 |
| ▸ | CYP3A43 | Q9HB55 | 2/20 | 0.64 |
| ▸ | PSMB9 | P28065 | 2/20 | 0.64 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.64 |
| ▸ | PSMD11 | O00231 | 1/20 | 0.64 |
| ▸ | PSMD12 | O00232 | 1/20 | 0.64 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.64 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.64 |
| ▸ | PSMD3 | O43242 | 1/20 | 0.64 |
| ▸ | CTSB | P07858 | 1/20 | 0.64 |
| ▸ | PSMC3 | P17980 | 1/20 | 0.64 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.64 |
| ▸ | PSMA1 | P25786 | 1/20 | 0.64 |
| ▸ | PSMA2 | P25787 | 1/20 | 0.64 |
| ▸ | PSMA3 | P25788 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8267511 | 0.94 | CTRL (0.68) | CTRLTMPRSS11DPSMB5CYP3A4CYP3A5 | |
| SCHEMBL13019269 | 0.91 | PSMB5 (0.58) | CTRLTMPRSS11DPSMB5CYP3A4CYP3A5 | |
| SCHEMBL84517 | 0.90 | PSMB5 (0.69) | CTRLTMPRSS11DPSMB5CYP3A4CYP3A5 | |
| SCHEMBL18257553 | 0.89 | CTRL (0.80) | CTRLTMPRSS11DPSMB5CYP3A4CYP3A5 | |
| SCHEMBL8075093 | 0.89 | CTRL (0.80) | CTRLTMPRSS11DPSMB5CYP3A4CYP3A5 | |
| SCHEMBL23616318 | 0.89 | CTRL (0.80) | CTRLTMPRSS11DPSMB5CYP3A4CYP3A5 | |
| SCHEMBL18257561 | 0.89 | CTRL (0.80) | CTRLTMPRSS11DPSMB5CYP3A4CYP3A5 | |
| SCHEMBL8080983 | 0.89 | CTRL (0.80) | CTRLTMPRSS11DPSMB5CYP3A4CYP3A5 | |
| SCHEMBL20825238 | 0.89 | CTRL (0.80) | CTRLTMPRSS11DPSMB5CYP3A4CYP3A5 | |
| SCHEMBL20218351 | 0.89 | CTRL (0.80) | CTRLTMPRSS11DPSMB5CYP3A4CYP3A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2266999-A2 | Compounds for proteasome enzym inhibition | Onyx Therapeutics, Inc. (US) | 2010-12-29 | — | — | EP | disclosed |