Known targets — ChEMBL curated mechanism
SLC6A2SLC6A3SSTR1SSTR2SSTR3SSTR5
The experimentally established mechanism targets of Aspartic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.38 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.36 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.36 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.36 |
| ▸ | GRM8 | O00222 | 1/20 | 0.36 |
| ▸ | GRM6 | O15303 | 1/20 | 0.36 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.36 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.36 |
| ▸ | GSR | P00390 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.36 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.36 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.36 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.36 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aspartic Acid SCHEMBL10455864 | 1.00 | SLC22A6 (0.38) | SLC22A6GABRR1LMNATDP1GRIK1 | |
| Aspartic Acid SCHEMBL376347 | 0.97 | SLC22A6 (0.39) | SLC22A6GABRR1LMNATDP1GRIK1 | |
| Aspartic Acid SCHEMBL2728797 | 0.97 | SLC22A6 (0.39) | SLC22A6GABRR1LMNATDP1GRIK1 | |
| Aspartic Acid SCHEMBL4195248 | 0.95 | TDP1 (0.42) | SLC22A6GABRR1LMNATDP1GRIK1 | |
| Aspartic Acid SCHEMBL1300893 | 0.95 | SLC22A6 (0.38) | SLC22A6GABRR1LMNATDP1GRIK1 | |
| Aspartic Acid SCHEMBL17350094 | 0.95 | SLC22A6 (0.38) | SLC22A6GABRR1LMNATDP1GRIK1 | |
| Aspartic Acid SCHEMBL4018865 | 0.95 | SLC22A6 (0.38) | SLC22A6GABRR1LMNATDP1GRIK1 | |
| Aspartic Acid SCHEMBL10455863 | 0.95 | SLC22A6 (0.38) | SLC22A6GABRR1LMNATDP1GRIK1 | |
| Aspartic Acid SCHEMBL1303172 | 0.95 | SLC22A6 (0.38) | SLC22A6GABRR1LMNATDP1GRIK1 | |
| Aspartic Acid SCHEMBL1938075 | 0.95 | SLC22A6 (0.38) | SLC22A6GABRR1LMNATDP1GRIK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100129445-A1 | GASTRORETENTIVE SYSTEM COMPRISING AN ALGINATE BODY | LTS LOHMANN THERAPIE-SYSTEME AG (DE) | 2010-05-27 | — | — | US | claimed |
| US-20180104185-A1 | LIQUID COMPOSITIONS CAPABLE OF FOAMING AND INCLUDING ACTIVE AGENTS, AND METHODS FOR MAKING OR DEVELOPING SAME | MIKA PHARMA GMBH | 2018-04-19 | — | — | US | disclosed |
| US-9693956-B2 | Liquid compositions capable of foaming and including active agents, and methods for making or developing same | MIKA PHARMA GMBH | 2017-07-04 | — | — | US | disclosed |
| US-20160022579-A1 | Liquid Compositions Capable of Foaming and Including Active Agents, and Methods for Making or Developing Same | MIKA PHARMA GMBH | 2016-01-28 | — | — | US | disclosed |
| US-9005626-B2 | Liquid compositions capable of foaming and including active agents, and methods for making or developing same | MIKA PHARMA GMBH (DE) | 2015-04-14 | — | — | US | disclosed |
| US-20110269704-A1 | METHOD FOR DEVELOPING A LIQUID COMPOSITION TO BE APPLIED TO THE SKIN AS A FOAM AND A COMPOSITION THAT CAN BE APPLIED TOPICALLY | MIKA PHARMA GESELLSCHAFT FUR DIE ENTWICKLUNG UND VERMARKTUNG PHARMAZEUTISCHER PRODUKTE MBH (DE) | 2011-11-03 | — | — | US | disclosed |
| US-20110059117-A1 | Liquid Compositions Capable of Foaming and Including Active Agents, and Methods for Making or Developing Same | MIKA PHARMA GMBH (DE) | 2011-03-10 | — | — | US | disclosed |