Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 19/20 | 0.53 |
| ▸ | BRAF | P15056 | 19/20 | 0.53 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.48 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.48 |
| ▸ | ERN1 | O75460 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.47 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.47 |
| ▸ | HIPK1 | Q86Z02 | 1/20 | 0.47 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2745578 | 0.93 | RAF1 (0.55) | RAF1BRAFPTK2CDK19ERN1 | |
| SCHEMBL2745963 | 0.87 | RAF1 (0.53) | RAF1BRAFPTK2CDK19ERN1 | |
| SCHEMBL2746031 | 0.84 | RAF1 (0.61) | RAF1BRAFERN1ABL1FGFR1 | |
| SCHEMBL2746718 | 0.83 | BRAF (0.60) | RAF1BRAFERN1ABL1FGFR1 | |
| SCHEMBL2745611 | 0.80 | BRAF (0.48) | RAF1BRAFERN1ABL1FGFR1 | |
| SCHEMBL2746370 | 0.80 | RAF1 (0.62) | RAF1BRAFERN1ABL1FGFR1 | |
| SCHEMBL14392018 | 0.80 | RAF1 (0.57) | RAF1BRAFPTK2CDK19ERN1 | |
| SCHEMBL3811246 | 0.79 | RAF1 (0.61) | RAF1BRAFERN1ABL1FGFR1 | |
| SCHEMBL2745625 | 0.79 | RAF1 (0.55) | RAF1BRAFERN1ABL1FGFR1 | |
| SCHEMBL2745347 | 0.78 | RAF1 (0.55) | RAF1BRAFPTK2CDK19ERN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2258704-A1 | Synthesis of imidazooxazole and imidazothiazole inhibitors of p38 map kinase | ArQule, Inc. (US) | 2010-12-08 | — | — | EP | disclosed |