Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 4/20 | 0.44 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.42 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.42 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.42 |
| ▸ | GSK3A | P49840 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.42 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.42 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.42 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.42 |
| ▸ | CSNK1G3 | Q9Y6M4 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 9/20 | 0.38 |
| ▸ | EGFR | P00533 | 9/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13022393 | 0.85 | BRAF (0.48) | BRAFTAOK1MAP4K4PRKD3CDK2 | |
| SCHEMBL2746204 | 0.81 | EGFR (0.49) | BRAFTAOK1MAP4K4PRKD3CDK2 | |
| SCHEMBL2746248 | 0.79 | BRAF (0.48) | BRAFTAOK1MAP4K4PRKD3CDK2 | |
| SCHEMBL2746185 | 0.79 | BRAF (0.48) | BRAFTAOK1MAP4K4PRKD3CDK2 | |
| SCHEMBL3810706 | 0.76 | BRAF (0.63) | BRAFTAOK1MAP4K4PRKD3CDK2 | |
| SCHEMBL2745347 | 0.75 | RAF1 (0.55) | BRAFMAPK8PTK2CDK19FGFR1 | |
| SCHEMBL2754169 | 0.75 | BRAF (0.49) | BRAFTAOK1MAP4K4PRKD3CDK2 | |
| SCHEMBL3808892 | 0.73 | MAPK8 (0.73) | BRAFTAOK1MAP4K4PRKD3CDK2 | |
| SCHEMBL2745330 | 0.73 | BRAF (0.54) | BRAFTAOK1MAP4K4PRKD3MAPK1 | |
| SCHEMBL2746612 | 0.72 | BRAF (0.60) | BRAFTAOK1MAP4K4PRKD3CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2258704-A1 | Synthesis of imidazooxazole and imidazothiazole inhibitors of p38 map kinase | ArQule, Inc. (US) | 2010-12-08 | — | — | EP | disclosed |