Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 11/20 | 0.48 |
| ▸ | PIM3 | Q86V86 | 3/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 4/20 | 0.45 |
| ▸ | GSK3A | P49840 | 3/20 | 0.45 |
| ▸ | ATR | Q13535 | 1/20 | 0.43 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.42 |
| ▸ | PRKCA | P17252 | 1/20 | 0.42 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.42 |
| ▸ | WDR5 | P61964 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13027817 | 0.88 | CHEK1 (0.51) | CHEK1PIM3PIM1GSK3BGSK3A | |
| SCHEMBL13027893 | 0.85 | CHEK1 (0.49) | CHEK1PIM3PIM1GSK3BGSK3A | |
| SCHEMBL13027865 | 0.82 | CHEK1 (0.51) | CHEK1PIM3PIM1GSK3BGSK3A | |
| SCHEMBL13027930 | 0.82 | PIM1 (0.52) | CHEK1PIM3PIM1GSK3BGSK3A | |
| SCHEMBL13027779 | 0.82 | CHEK1 (0.58) | CHEK1PIM3PIM1GSK3BGSK3A | |
| SCHEMBL13027885 | 0.82 | CHEK1 (0.51) | CHEK1PIM3PIM1GSK3BGSK3A | |
| SCHEMBL13027832 | 0.81 | PIM1 (0.55) | CHEK1PIM3PIM1GSK3BGSK3A | |
| SCHEMBL13028332 | 0.81 | PIM1 (0.57) | CHEK1PIM3PIM1GSK3BGSK3A | |
| SCHEMBL13027878 | 0.81 | PIM1 (0.51) | CHEK1PIM3PIM1GSK3BGSK3A | |
| SCHEMBL13027822 | 0.81 | CHEK1 (0.57) | CHEK1PIM3PIM1GSK3BGSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10774070-B2 | 2-(pyridin-3-yl)-pyrimidine derivatives as RET inhibitors | BLUEPRINT MEDICINES CORPORATION (US) | 2020-09-15 | — | — | US | disclosed |
| US-10202365-B2 | 2-(pyridin-3-yl)-pyrimidine derivatives as RET inhibitors | BLUEPRINT MEDICINES CORPORATION (US) | 2019-02-12 | — | — | US | disclosed |
| US-20180022731-A1 | 2-(PYRIDIN-3-YL)-PYRIMIDINE DERIVATIVES AS RET INHIBITORS | BLUEPRINT MEDICINES CORPORATION | 2018-01-25 | — | — | US | disclosed |
| US-20180022731-A1 | 2-(PYRIDIN-3-YL)-PYRIMIDINE DERIVATIVES AS RET INHIBITORS | BLUEPRINT MEDICINES CORPORATION | 2018-01-25 | — | — | US | disclosed |
| WO-2016127074-A1 | 2-(PYRIDIN-3-YL)-PYRIMIDINE DERIVATIVES AS RET INHIBITORS | BLUEPRINT MEDICINES CORPORATION (US) | 2016-08-11 | — | — | WO | disclosed |
| US-8293747-B2 | Heterocyclic amide compounds as protein kinase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2012-10-23 | — | — | US | disclosed |
| US-8293747-B2 | Heterocyclic amide compounds as protein kinase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2012-10-23 | — | — | US | disclosed |
| US-20100286135-A1 | HETEROCYCLIC AMIDE COMPOUNDS AS PROTEIN KINASE INHIBITORS | Schering Corporation Patent Department, K-6-1; 1990 (US) | 2010-11-11 | — | — | US | disclosed |
| US-20100286135-A1 | HETEROCYCLIC AMIDE COMPOUNDS AS PROTEIN KINASE INHIBITORS | Schering Corporation Patent Department, K-6-1; 1990 (US) | 2010-11-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100286135-A1 | HETEROCYCLIC AMIDE COMPOUNDS AS PROTEIN KINASE INHIBITORS | MTOR, CDK1, MAP3K8 | CHEK1 113/4885PIM3 929/4885PIM1 677/4885 |
| US-10202365-B2 | 2-(pyridin-3-yl)-pyrimidine derivatives as RET inhibitors | RET, BRAF, RB1 | CHEK1 970/4885PIM3 2450/4885PIM1 2417/4885 |
| US-10774070-B2 | 2-(pyridin-3-yl)-pyrimidine derivatives as RET inhibitors | RET, BRAF, RB1 | CHEK1 970/4885PIM3 2450/4885PIM1 2417/4885 |
| US-20180022731-A1 | 2-(PYRIDIN-3-YL)-PYRIMIDINE DERIVATIVES AS RET INHIBITORS | RET, MECP2, RB1 | CHEK1 477/4885PIM3 2020/4885PIM1 2313/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.