Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 5/20 | 0.41 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.41 |
| ▸ | KCNA1 | Q09470 | 1/20 | 0.41 |
| ▸ | SSTR1 | P30872 | 4/20 | 0.41 |
| ▸ | SSTR2 | P30874 | 4/20 | 0.41 |
| ▸ | SSTR4 | P31391 | 4/20 | 0.41 |
| ▸ | SSTR3 | P32745 | 4/20 | 0.41 |
| ▸ | SSTR5 | P35346 | 4/20 | 0.41 |
| ▸ | KLK7 | P49862 | 1/20 | 0.40 |
| ▸ | NPR1 | P16066 | 1/20 | 0.40 |
| ▸ | NPR3 | P17342 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 6/20 | 0.39 |
| ▸ | IL23R | Q5VWK5 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13029975 | 0.98 | KCNA3 (0.44) | MDM2KCNA3KCNA1SSTR1SSTR2 | |
| SCHEMBL13029983 | 0.96 | MDM2 (0.42) | MDM2SSTR1SSTR2SSTR4SSTR3 | |
| SCHEMBL18033736 | 0.94 | KCNA3 (0.44) | MDM2KCNA3KCNA1KLK7NPR1 | |
| SCHEMBL13030005 | 0.93 | MDM2 (0.43) | MDM2KCNA3KCNA1SSTR1SSTR2 | |
| SCHEMBL18516867 | 0.92 | SSTR1 (0.40) | MDM2KCNA3KCNA1SSTR1SSTR2 | |
| SCHEMBL18516888 | 0.90 | MDM2 (0.41) | MDM2KCNA3KCNA1SSTR1SSTR2 | |
| SCHEMBL13030017 | 0.90 | MDM2 (0.42) | MDM2KCNA3KCNA1SSTR1SSTR2 | |
| SCHEMBL13030021 | 0.89 | MDM2 (0.41) | MDM2KCNA3KCNA1SSTR1SSTR2 | |
| SCHEMBL18516885 | 0.88 | MDM2 (0.42) | MDM2KCNA3KCNA1SSTR1SSTR2 | |
| SCHEMBL13030011 | 0.86 | MDM2 (0.39) | MDM2KCNA3KCNA1SSTR1SSTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170043020-A1 | ANTIBODY-MEDIATED DISRUPTION OF QUORUM SENSING IN BACTERIA | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2017-02-16 | — | — | US | disclosed |
| US-9394371-B2 | Antibody-mediated disruption of quorum sensing in bacteria | THE SCRIPPS RESEARCH INSTITUTE (US) | 2016-07-19 | — | — | US | disclosed |
| US-20100291093-A1 | ANTIBODY-MEDIATED DISRUPTION OF QUORUM SENSING IN BACTERIA | THE SCRIPPS RESEARCH INSTITUTE (US) | 2010-11-18 | — | — | US | disclosed |
| US-20100291093-A1 | ANTIBODY-MEDIATED DISRUPTION OF QUORUM SENSING IN BACTERIA | THE SCRIPPS RESEARCH INSTITUTE (US) | 2010-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170043020-A1 | ANTIBODY-MEDIATED DISRUPTION OF QUORUM SENSING IN BACTERIA | CD47, TLR5, ANTXR2 | MDM2 2945/4885KCNA3 2456/4885KCNA1 2683/4885 |
| US-20100291093-A1 | ANTIBODY-MEDIATED DISRUPTION OF QUORUM SENSING IN BACTERIA | CD47, BCR, TLR5 | MDM2 2389/4885KCNA3 2802/4885KCNA1 3084/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.