Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | YES1 | P07947 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.39 |
| ▸ | CLK1 | P49759 | 1/20 | 0.39 |
| ▸ | CLK2 | P49760 | 1/20 | 0.39 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.39 |
| ▸ | CDC7 | O00311 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.37 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1302835 | 0.86 | MAPK1 (0.43) | MAPK1NTRK1YES1PIM1AURKB | |
| SCHEMBL1302602 | 0.82 | MAP3K5 (0.51) | PIK3CAPIK3CDPIK3CBPIK3CGCLK1 | |
| SCHEMBL1302528 | 0.81 | PIK3CA (0.44) | MAPK1NTRK1YES1PIM1AURKB | |
| SCHEMBL1302385 | 0.79 | PIK3CG (0.45) | AURKBPIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL1302670 | 0.79 | MAP3K5 (0.44) | PIK3CAPIK3CDPIK3CBPIK3CGCLK1 | |
| SCHEMBL1303285 | 0.78 | BRAF (0.43) | PIK3CAPIK3CDPIK3CBPIK3CGCLK1 | |
| SCHEMBL1303473 | 0.78 | MAP3K5 (0.48) | PIK3CAPIK3CDPIK3CBPIK3CGCLK1 | |
| SCHEMBL1303576 | 0.77 | PIK3CA (0.42) | PIK3CAPIK3CDPIK3CBPIK3CGCLK1 | |
| SCHEMBL1303491 | 0.77 | PIK3CA (0.41) | PIK3CAPIK3CDPIK3CBPIK3CGCLK1 | |
| SCHEMBL3140620 | 0.75 | PIK3CA (0.63) | PIK3CAPIK3CDPIK3CBPIK3CGCLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8053574-B2 | Organic compounds | NOVARTIS AG (CH) | 2011-11-08 | — | — | US | disclosed |
| US-20100197682-A1 | Organic Compounds | NOVARTIS AG | 2010-08-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100197682-A1 | Organic Compounds | PIK3CA, PI4KA, PI4KB | CREBBP 864/4885MAPK1 302/4885NTRK1 668/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.