Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC29A1 | Q99808 | 8/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.43 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CRHR1 | P34998 | 4/20 | 0.38 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13034404 | 0.90 | SLC29A1 (0.50) | SLC29A1ALDH1A1LMNATDP1KMT2A | |
| SCHEMBL15107930 | 0.88 | SLC29A1 (0.46) | SLC29A1ALDH1A1LMNAHCRTR1HCRTR2 | |
| SCHEMBL12986119 | 0.85 | SLC29A1 (0.44) | SLC29A1ALDH1A1LMNAHCRTR1HCRTR2 | |
| SCHEMBL12871103 | 0.84 | TDP1 (0.44) | ALDH1A1LMNAHCRTR1HCRTR2HTT | |
| SCHEMBL12169523 | 0.83 | SLC29A1 (0.64) | SLC29A1ALDH1A1LMNAHTTTDP1 | |
| SCHEMBL12871102 | 0.83 | TDP1 (0.53) | ALDH1A1LMNAHCRTR1HCRTR2HTT | |
| SCHEMBL13034403 | 0.80 | SLC29A1 (0.45) | SLC29A1ALDH1A1LMNAHTTTDP1 | |
| SCHEMBL11403187 | 0.78 | SLC29A1 (0.43) | SLC29A1ALDH1A1LMNATDP1KMT2A | |
| SCHEMBL11766019 | 0.77 | SLC29A1 (0.68) | SLC29A1ALDH1A1LMNAHTTTDP1 | |
| SCHEMBL12295196 | 0.76 | HCRTR1 (0.42) | ALDH1A1LMNAHCRTR1HCRTR2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8486950-B2 | Janus kinase inhibitor compounds and methods | F. HOFFMANN-LA ROCHE AG (CH) | 2013-07-16 | — | — | US | disclosed |
| US-20100317643-A1 | JANUS KINASE INHIBITOR COMPOUNDS AND METHODS | GENENTECH, INC. (US) | 2010-12-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100317643-A1 | JANUS KINASE INHIBITOR COMPOUNDS AND METHODS | JAK2, JAK1, JAK3 | SLC29A1 4043/4885ALDH1A1 1560/4885LMNA 4561/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.