Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 5/20 | 0.60 |
| ▸ | CCNB1 | P14635 | 5/20 | 0.60 |
| ▸ | CDK2 | P24941 | 4/20 | 0.60 |
| ▸ | CDC7 | O00311 | 3/20 | 0.60 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.60 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.60 |
| ▸ | PRKACA | P17612 | 2/20 | 0.60 |
| ▸ | GSK3B | P49841 | 2/20 | 0.60 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.60 |
| ▸ | HIPK2 | Q9H2X6 | 2/20 | 0.60 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.60 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.60 |
| ▸ | RET | P07949 | 2/20 | 0.60 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.60 |
| ▸ | CDK4 | P11802 | 3/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.43 |
| ▸ | CCND1 | P24385 | 3/20 | 0.43 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.43 |
| ▸ | VCP | P55072 | 1/20 | 0.42 |
| ▸ | IDH1 | O75874 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13039335 | 1.00 | CDK1 (0.60) | CDK1CCNB1CDK2CDC7CCNB2 | |
| SCHEMBL13039368 | 0.94 | CDK1 (0.52) | CDK1CCNB1CDK2CDC7CCNB2 | |
| SCHEMBL13039319 | 0.82 | HPGD (0.45) | CDK1CCNB1CDK2CDC7CCNB2 | |
| SCHEMBL13039316 | 0.82 | CDK1 (0.63) | CDK1CCNB1CDK2CDC7CCNB2 | |
| SCHEMBL13039318 | 0.82 | CDK1 (0.63) | CDK1CCNB1CDK2CDC7CCNB2 | |
| SCHEMBL13039317 | 0.81 | CDK1 (0.62) | CDK1CCNB1CDK2CDC7CCNB2 | |
| SCHEMBL13039333 | 0.78 | CDK1 (0.59) | CDK1CCNB1CDK2CDC7CCNB2 | |
| SCHEMBL13805582 | 0.78 | CDK2 (0.37) | CDK1CCNB1CDK2CDC7CCNB2 | |
| SCHEMBL13039328 | 0.78 | CDK4 (0.55) | CDK1CCNB1CDK2CDC7CCNB2 | |
| SCHEMBL13039345 | 0.77 | MKNK1 (0.51) | CDK1CCNB1CDK2CCNB2GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8367687-B2 | Pyrazole derivatives | NOVARTIS AG (CH) | 2013-02-05 | — | — | US | disclosed |
| US-8367687-B2 | Pyrazole derivatives | NOVARTIS AG (CH) | 2013-02-05 | — | — | US | disclosed |
| US-20100280033-A1 | Pyrazole Derivatives | NOVARTIS AG | 2010-11-04 | — | — | US | disclosed |
| US-20100280033-A1 | Pyrazole Derivatives | NOVARTIS AG | 2010-11-04 | — | — | US | disclosed |
| WO-2009071701-A1 | PYRAZOLE DERIVATIVES AND USE THEREOF AS INHIBITORS OF CYCLIN DEPENDENT KINASES | NOVARTIS AG (CH) | 2009-06-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100280033-A1 | Pyrazole Derivatives | PRKDC, PRKACA, PDK2 | CDK1 58/4885CCNB1 960/4885CDK2 16/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.