Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAV | P06756 | 20/20 | 0.58 |
| ▸ | ITGB6 | P18564 | 18/20 | 0.58 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.58 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.58 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.58 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.58 |
| ▸ | ITGB8 | P26012 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL328157 | 0.92 | ITGAV (0.59) | ITGAVITGB6ITGB3ITGB1ITGA5 | |
| SCHEMBL328135 | 0.92 | ITGAV (0.67) | ITGAVITGB6ITGB3ITGB1ITGA5 | |
| SCHEMBL13039585 | 0.91 | ITGAV (0.57) | ITGAVITGB6ITGB3ITGB1ITGA5 | |
| SCHEMBL10200502 | 0.91 | ITGAV (0.60) | ITGAVITGB6ITGB3ITGB1ITGA5 | |
| SCHEMBL13039587 | 0.91 | ITGAV (0.56) | ITGAVITGB6ITGB3ITGB1ITGA5 | |
| SCHEMBL13039582 | 0.89 | ITGAV (0.59) | ITGAVITGB6ITGB3ITGB1ITGA5 | |
| SCHEMBL13039589 | 0.88 | ITGAV (0.58) | ITGAVITGB6ITGB3ITGB1ITGA5 | |
| SCHEMBL13039591 | 0.86 | ITGAV (0.58) | ITGAVITGB6ITGB3ITGB1ITGA5 | |
| SCHEMBL21776208 | 0.84 | ITGAV (0.66) | ITGAVITGB6ITGB3ITGB1ITGA5 | |
| SCHEMBL328042 | 0.83 | ITGAV (0.64) | ITGAVITGB6ITGB3ITGB1ITGA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7825119-B2 | Bone disorders such as osteoporosis, tumors and cardiovascular disorders; 4-(2-carboxy-2-Boc-aminoethylamino)-6-piperidinopyrimidines such as tert-butyl 2-benzyloxycarbonylamino-3-[2,5-dimethoxy-6-(4-[1,8]naphthyridin-2-yl-piperidin-1-yl)pyrimidin-4-ylamino]-propionate | GALAPAGOS SAS (FR) | 2010-11-02 | — | — | US | disclosed |
| US-7825119-B2 | Bone disorders such as osteoporosis, tumors and cardiovascular disorders; 4-(2-carboxy-2-Boc-aminoethylamino)-6-piperidinopyrimidines such as tert-butyl 2-benzyloxycarbonylamino-3-[2,5-dimethoxy-6-(4-[1,8]naphthyridin-2-yl-piperidin-1-yl)pyrimidin-4-ylamino]-propionate | GALAPAGOS SAS (FR) | 2010-11-02 | — | — | US | disclosed |