Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 6/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.36 |
| ▸ | USP19 | O94966 | 6/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.32 |
| ▸ | FEN1 | P39748 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3729060 | 0.84 | BACE1 (0.73) | BACE1MAPK1SCD5USP19ALOX5AP | |
| SCHEMBL3739326 | 0.84 | BACE1 (0.72) | BACE1MAPK1SCD5USP19ALOX5AP | |
| SCHEMBL3736070 | 0.83 | BACE1 (0.81) | BACE1MAPK1SCD5USP19TMEM97 | |
| SCHEMBL3739470 | 0.82 | BACE1 (0.70) | BACE1MAPK1HDAC6HDAC8HDAC1 | |
| SCHEMBL4230395 | 0.82 | BACE1 (0.79) | BACE1MAPK1SCD5USP19ALOX5AP | |
| SCHEMBL3736938 | 0.82 | BACE1 (0.79) | BACE1MAPK1SCD5USP19ALOX5AP | |
| SCHEMBL3734063 | 0.82 | BACE1 (0.79) | BACE1MAPK1SCD5USP19ALOX5AP | |
| SCHEMBL3737164 | 0.81 | BACE1 (1.00) | BACE1MAPK1SCD5 | |
| SCHEMBL3737168 | 0.81 | BACE1 (1.00) | BACE1MAPK1SCD5 | |
| SCHEMBL15988501 | 0.81 | BACE1 (0.78) | BACE1MAPK1SCD5USP19HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100280009-A1 | 3,4-SUBSTITUTED PYRROLIDINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME LLC | 2010-11-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100280009-A1 | 3,4-SUBSTITUTED PYRROLIDINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | BACE1, BACE2, PSEN1 | BACE1 1/4885MAPK1 3490/4885SCD5 685/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.