Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.53 |
| ▸ | RET | P07949 | 3/20 | 0.53 |
| ▸ | KIT | P10721 | 2/20 | 0.53 |
| ▸ | RAF1 | P04049 | 1/20 | 0.53 |
| ▸ | LCK | P06239 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.53 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.53 |
| ▸ | FLT1 | P17948 | 4/20 | 0.46 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.37 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3731838 | 0.93 | KDR (0.52) | KDRRETKITRAF1LCK | |
| SCHEMBL3732453 | 0.93 | KDR (0.59) | KDRRETKITRAF1LCK | |
| SCHEMBL3738330 | 0.93 | KDR (0.51) | KDRRETKITRAF1LCK | |
| SCHEMBL3735497 | 0.93 | KDR (0.51) | KDRRETKITRAF1LCK | |
| SCHEMBL3735473 | 0.92 | KDR (0.51) | KDRRETKITRAF1LCK | |
| SCHEMBL13043337 | 0.91 | KDR (0.50) | KDRRETKITRAF1LCK | |
| SCHEMBL3748316 | 0.90 | KDR (0.50) | KDRRETKITRAF1LCK | |
| SCHEMBL3745989 | 0.90 | KDR (0.48) | KDRRETKITRAF1LCK | |
| SCHEMBL3731993 | 0.89 | KDR (0.49) | KDRRETKITRAF1LCK | |
| SCHEMBL3735052 | 0.88 | KDR (0.51) | KDRRETKITRAF1LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7829717-B2 | (Arylamidoaryl)squaramide compounds | OSI PHARMACEUTICALS, INC. (US) | 2010-11-09 | — | — | US | disclosed |
| US-7829717-B2 | (Arylamidoaryl)squaramide compounds | OSI PHARMACEUTICALS, INC. (US) | 2010-11-09 | — | — | US | disclosed |