Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 19/20 | 0.60 |
| ▸ | JAK2 | O60674 | 17/20 | 0.60 |
| ▸ | JAK1 | P23458 | 10/20 | 0.60 |
| ▸ | CDK9 | P50750 | 1/20 | 0.50 |
| ▸ | JAK3 | P52333 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13032671 | 0.88 | TYK2 (0.57) | TYK2JAK2JAK1CDK9JAK3 | |
| SCHEMBL3517458 | 0.86 | TYK2 (0.59) | TYK2JAK2JAK1CDK9JAK3 | |
| SCHEMBL3513617 | 0.85 | JAK2 (0.54) | TYK2JAK2JAK1 | |
| SCHEMBL3514600 | 0.84 | TYK2 (0.70) | TYK2JAK2JAK1CDK9JAK3 | |
| SCHEMBL3514268 | 0.83 | TYK2 (0.69) | TYK2JAK2JAK1CDK9JAK3 | |
| SCHEMBL12987231 | 0.83 | TYK2 (0.71) | TYK2JAK2JAK1CDK9JAK3 | |
| SCHEMBL3516473 | 0.83 | TYK2 (0.55) | TYK2JAK2JAK1EGFR | |
| SCHEMBL13043157 | 0.80 | TYK2 (0.73) | TYK2JAK2JAK1CDK9JAK3 | |
| SCHEMBL3513033 | 0.80 | TYK2 (0.66) | TYK2JAK2JAK1CDK9JAK3 | |
| SCHEMBL3516487 | 0.79 | TYK2 (0.62) | TYK2JAK2JAK1CDK9JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010142752-A1 | JANUS KINASE INHIBITOR COMPOUNDS AND METHODS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-12-16 | — | — | WO | disclosed |