Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 6/20 | 0.42 |
| ▸ | NPC1 | O15118 | 7/20 | 0.40 |
| ▸ | RAB9A | P51151 | 7/20 | 0.40 |
| ▸ | RAF1 | P04049 | 2/20 | 0.38 |
| ▸ | BRAF | P15056 | 2/20 | 0.38 |
| ▸ | KIT | P10721 | 2/20 | 0.38 |
| ▸ | SRC | P12931 | 2/20 | 0.38 |
| ▸ | FLT3 | P36888 | 2/20 | 0.38 |
| ▸ | ITK | Q08881 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1040923 | 0.92 | BTK (0.42) | BTKNPC1RAB9ARAF1BRAF | |
| SCHEMBL1038537 | 0.84 | BTK (0.56) | BTKNPC1RAB9ASRCFLT3 | |
| SCHEMBL12956112 | 0.82 | BTK (0.52) | BTKRAB9A | |
| SCHEMBL1042485 | 0.81 | BTK (0.43) | BTKNPC1RAB9AKITSRC | |
| SCHEMBL1039939 | 0.81 | BTK (0.51) | BTKNPC1RAB9ARAF1BRAF | |
| SCHEMBL1038028 | 0.81 | BTK (0.49) | BTKNPC1RAB9ASRC | |
| SCHEMBL1038372 | 0.80 | FLT3 (0.53) | BTKKITSRCFLT3ITK | |
| SCHEMBL12956116 | 0.80 | BTK (0.50) | BTKRAB9A | |
| SCHEMBL1041847 | 0.79 | BTK (0.52) | BTKSRCFLT3ITK | |
| SCHEMBL1038359 | 0.78 | BTK (0.59) | BTKKITSRCFLT3ITK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7838523-B2 | Certain substituted amides, method of making, and method of use thereof | CGI PHARMACEUTICALS, INC. (US) | 2010-11-23 | — | — | US | disclosed |