Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 5/20 | 0.59 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.59 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.59 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.59 |
| ▸ | CDK4 | P11802 | 8/20 | 0.53 |
| ▸ | CCND1 | P24385 | 5/20 | 0.53 |
| ▸ | CCND3 | P30281 | 3/20 | 0.53 |
| ▸ | CDK6 | Q00534 | 3/20 | 0.53 |
| ▸ | KDR | P35968 | 2/20 | 0.47 |
| ▸ | CDK1 | P06493 | 5/20 | 0.47 |
| ▸ | CCNB1 | P14635 | 5/20 | 0.47 |
| ▸ | CDK2 | P24941 | 5/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.47 |
| ▸ | CCNA1 | P78396 | 4/20 | 0.47 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.47 |
| ▸ | PDE5A | O76074 | 4/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5430843 | 0.98 | MAPK9 (0.59) | PDE4BMAPK9MAPK10PDE10ACDK4 | |
| SCHEMBL3205166 | 0.96 | PDE4B (0.59) | PDE4BMAPK9MAPK10PDE10ACDK4 | |
| SCHEMBL5426757 | 0.85 | MAPK9 (0.52) | PDE4BMAPK9MAPK10PDE10ACDK4 | |
| SCHEMBL3195011 | 0.85 | PDE4B (0.69) | PDE4BMAPK9MAPK10PDE10ACDK4 | |
| SCHEMBL13042835 | 0.83 | PDE4B (0.55) | PDE4BMAPK9MAPK10PDE10ACDK4 | |
| SCHEMBL5426190 | 0.83 | MAPK9 (0.56) | PDE4BMAPK9MAPK10PDE10ACDK4 | |
| SCHEMBL5209413 | 0.83 | MAPK9 (0.55) | PDE4BMAPK9MAPK10PDE10ACDK4 | |
| SCHEMBL5439220 | 0.82 | MAPK9 (0.56) | PDE4BMAPK9MAPK10PDE10ACDK4 | |
| SCHEMBL5439136 | 0.81 | MAPK9 (0.74) | PDE4BMAPK9MAPK10PDE10ACDK4 | |
| SCHEMBL5421761 | 0.80 | CDK4 (0.50) | PDE4BMAPK9MAPK10PDE10ACDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010144416-A1 | SUBSTITUTED PYRAZOLO [1,5-a] PYRIDINE COMPOUNDS HAVING MULTI-TARGET ACTIVITY | GAETA FEDERICO C A (US) | 2010-12-16 | — | — | WO | disclosed |