Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 2/20 | 0.64 |
| ▸ | METAP1 | P53582 | 6/20 | 0.61 |
| ▸ | CA12 | O43570 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | CA7 | P43166 | 1/20 | 0.54 |
| ▸ | CA9 | Q16790 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | MDM4 | O15151 | 1/20 | 0.49 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | NPM1 | P06748 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4428107 | 0.84 | METAP1 (0.80) | PPARGMETAP1CA12CA1CA2 | |
| SCHEMBL5062824 | 0.84 | GSK3B (0.62) | PPARGMAPTKDM4EALDH1A1TDP1 | |
| SCHEMBL5062828 | 0.84 | GSK3B (0.62) | PPARGMAPTKDM4EALDH1A1TDP1 | |
| SCHEMBL14712873 | 0.80 | METAP1 (0.64) | PPARGMETAP1MAPTKDM4EALDH1A1 | |
| SCHEMBL14033557 | 0.79 | METAP1 (0.71) | PPARGMETAP1CA12CA1CA2 | |
| SCHEMBL16543019 | 0.76 | METAP1 (1.00) | METAP1CA12CA1CA2CA7 | |
| SCHEMBL28680183 | 0.76 | METAP1 (0.67) | METAP1CA12CA1CA2CA7 | |
| SCHEMBL21779711 | 0.76 | METAP1 (0.67) | PPARGMETAP1CA12CA1CA2 | |
| SCHEMBL8083180 | 0.76 | METAP1 (0.67) | METAP1CA12CA1CA2CA7 | |
| SCHEMBL31406586 | 0.76 | GSK3B (0.70) | METAP1CA12CA1CA2CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010136804-A1 | PYRIMIDINE DERIVATIVES FOR USE AS ANTIBIOTICS | ASTON UNIVERSITY (GB) | 2010-12-02 | — | — | WO | disclosed |