Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 20/20 | 0.67 |
| ▸ | JAK2 | O60674 | 11/20 | 0.65 |
| ▸ | JAK1 | P23458 | 6/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1706082 | 0.82 | TYK2 (0.79) | TYK2JAK2JAK1 | |
| SCHEMBL1707067 | 0.80 | TYK2 (1.00) | TYK2JAK2JAK1 | |
| SCHEMBL1706029 | 0.79 | TYK2 (1.00) | TYK2JAK2JAK1 | |
| SCHEMBL3517302 | 0.79 | TYK2 (0.64) | TYK2JAK2JAK1 | |
| SCHEMBL13044837 | 0.78 | TYK2 (0.80) | TYK2JAK2JAK1 | |
| SCHEMBL3556665 | 0.77 | TYK2 (0.79) | TYK2JAK2 | |
| SCHEMBL12988388 | 0.77 | TYK2 (0.79) | TYK2JAK2 | |
| SCHEMBL3553124 | 0.77 | TYK2 (0.79) | TYK2JAK2 | |
| SCHEMBL3553122 | 0.77 | TYK2 (0.79) | TYK2JAK2 | |
| SCHEMBL12989142 | 0.77 | TYK2 (0.79) | TYK2JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010142752-A1 | JANUS KINASE INHIBITOR COMPOUNDS AND METHODS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-12-16 | — | — | WO | disclosed |