Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 20/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.44 |
| ▸ | MTOR | P42345 | 1/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3718573 | 0.86 | PRKDC (0.54) | PRKDCPIK3CDBRD4PIK3CAPIK3CB | |
| SCHEMBL13049914 | 0.79 | PRKDC (0.49) | PRKDCPIK3CDBRD4PIK3CAPIK3CB | |
| SCHEMBL13049360 | 0.78 | PRKDC (0.56) | PRKDCPIK3CDBRD4PIK3CAPIK3CB | |
| SCHEMBL13049322 | 0.78 | PRKDC (0.51) | PRKDCPIK3CDBRD4PIK3CAPIK3CB | |
| SCHEMBL3714411 | 0.78 | PRKDC (0.57) | PRKDCPIK3CDBRD4PIK3CAPIK3CB | |
| SCHEMBL13049912 | 0.76 | PRKDC (0.53) | PRKDCPIK3CDBRD4PIK3CAPIK3CB | |
| SCHEMBL13049305 | 0.75 | PRKDC (0.60) | PRKDCPIK3CDBRD4PIK3CAPIK3CB | |
| SCHEMBL13050351 | 0.75 | PRKDC (0.63) | PRKDCPIK3CDBRD4PIK3CAPIK3CB | |
| SCHEMBL13049033 | 0.75 | PRKDC (0.57) | PRKDCPIK3CDBRD4PIK3CAPIK3CB | |
| SCHEMBL13050054 | 0.74 | PRKDC (0.54) | PRKDCPIK3CDBRD4PIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010136778-A1 | DIBENZOTHIOPHENE DERIVATIVES AS DNA- PK INHIBITORS | KUDOS PHARMACEUTICALS LIMITED (GB) | 2010-12-02 | — | — | WO | disclosed |