Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALCRL | Q16602 | 19/20 | 0.68 |
| ▸ | MAP2K2 | P36507 | 13/20 | 0.68 |
| ▸ | ADM2 | Q7Z4H4 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13053404 | 0.87 | CALCRL (0.73) | CALCRLMAP2K2ADM2 | |
| SCHEMBL3750981 | 0.86 | CALCRL (0.66) | CALCRLMAP2K2 | |
| SCHEMBL3634241 | 0.86 | CALCRL (0.66) | CALCRLMAP2K2 | |
| SCHEMBL13080897 | 0.85 | CALCRL (0.62) | CALCRLMAP2K2ADM2 | |
| SCHEMBL13053421 | 0.85 | CALCRL (0.77) | CALCRLMAP2K2ADM2 | |
| SCHEMBL13053394 | 0.85 | CALCRL (0.79) | CALCRLMAP2K2ADM2 | |
| SCHEMBL3745492 | 0.83 | CALCRL (0.62) | CALCRLMAP2K2ADM2 | |
| SCHEMBL3633375 | 0.83 | CALCRL (0.62) | CALCRLMAP2K2ADM2 | |
| SCHEMBL10246263 | 0.83 | CALCRL (0.59) | CALCRLMAP2K2ADM2 | |
| SCHEMBL13053525 | 0.83 | CALCRL (0.80) | CALCRLMAP2K2ADM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100292263-A1 | CGRP RECEPTOR ANTAGONISTS WITH TERTIARY AMIDE, SULFONAMIDE, CARBAMITE AND UREA GROUPS | MERCK SHARP & DOHME LLC | 2010-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100292263-A1 | CGRP RECEPTOR ANTAGONISTS WITH TERTIARY AMIDE, SULFONAMIDE, CARBAMITE AND UREA GROUPS | CALCR, QRFPR, CALCRL | CALCRL 3/4885MAP2K2 4273/4885ADM2 132/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.