Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 7/20 | 0.41 |
| ▸ | PGR | P06401 | 3/20 | 0.39 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.37 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CTSD | P07339 | 2/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.34 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | STK10 | O94804 | 1/20 | 0.33 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7570109 | 1.00 | BACE1 (0.41) | BACE1PGRBACE2PAX8ALDH1A1 | |
| SCHEMBL8210363 | 1.00 | BACE1 (0.41) | BACE1PGRBACE2PAX8ALDH1A1 | |
| SCHEMBL7574530 | 0.92 | BACE1 (0.39) | BACE1PGRBACE2ALDH1A1CTSD | |
| SCHEMBL13054721 | 0.92 | BACE1 (0.39) | BACE1PGRBACE2ALDH1A1CTSD | |
| SCHEMBL7555868 | 0.89 | BACE1 (0.39) | BACE1PGRBACE2ALDH1A1GRIA2 | |
| SCHEMBL8211523 | 0.89 | BACE1 (0.39) | BACE1PGRBACE2ALDH1A1GRIA2 | |
| SCHEMBL8414498 | 0.89 | BACE1 (0.37) | BACE1PGRBACE2ALDH1A1CTSD | |
| SCHEMBL7564419 | 0.89 | BACE1 (0.37) | BACE1PGRBACE2ALDH1A1CTSD | |
| SCHEMBL13054247 | 0.89 | BACE1 (0.39) | BACE1PGRBACE2ALDH1A1CTSD | |
| SCHEMBL7557016 | 0.89 | BACE1 (0.39) | BACE1PGRBACE2ALDH1A1CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100292203-A1 | HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS | SCHERING CORPORATION | 2010-11-18 | — | — | US | disclosed |
| US-20100292203-A1 | HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS | SCHERING CORPORATION | 2010-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100292203-A1 | HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS | CHRM1, CHRM2, PRSS1 | BACE1 8/4885PGR 1172/4885BACE2 30/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.