Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 2/20 | 0.42 |
| ▸ | CDK2 | P24941 | 12/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 10/20 | 0.38 |
| ▸ | CCNA1 | P78396 | 10/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13055361 | 0.95 | CCNA2 (0.39) | ROCK1CDK2CCNA2CCNA1 | |
| SCHEMBL13055356 | 0.88 | CDK2 (0.36) | ROCK1CDK2CCNA2CCNA1CCNE1 | |
| SCHEMBL13055283 | 0.84 | AR (0.41) | CDK2CCNA2CCNA1 | |
| SCHEMBL13055354 | 0.81 | ROCK1 (0.43) | ROCK1CDK9 | |
| SCHEMBL13055303 | 0.81 | CCNA2 (0.38) | CDK2CCNA2CCNA1 | |
| SCHEMBL13055326 | 0.80 | CDK2 (0.35) | CDK2CCNA2CCNA1CDK9CDK5 | |
| SCHEMBL13055368 | 0.80 | CDK2 (0.37) | CDK2CCNA2CCNA1CDK9CDK5 | |
| SCHEMBL13055353 | 0.79 | ROCK1 (0.43) | ROCK1 | |
| SCHEMBL13055704 | 0.78 | PARP15 (0.43) | CDK2CCNA2CCNA1CDK9CDK5 | |
| SCHEMBL13055407 | 0.77 | CDK2 (0.38) | CDK2CCNA2CCNA1CDK9CDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7842712-B2 | Indazolinone compositions useful as kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-11-30 | — | — | US | disclosed |
| US-7842712-B2 | Indazolinone compositions useful as kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-11-30 | — | — | US | disclosed |
| US-20090048250-A1 | INDAZOLINONE COMPOSITIONS USEFUL AS KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED | 2009-02-19 | — | — | US | disclosed |
| US-20090048250-A1 | INDAZOLINONE COMPOSITIONS USEFUL AS KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED | 2009-02-19 | — | — | US | disclosed |
| US-7262200-B2 | Indazolinone compositions useful as kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-08-28 | — | — | US | disclosed |
| US-7262200-B2 | Indazolinone compositions useful as kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-08-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090048250-A1 | INDAZOLINONE COMPOSITIONS USEFUL AS KINASE INHIBITORS | LCK, CDK2, MKNK2 | ROCK1 274/4885CDK2 2/4885CCNA2 333/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.