Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.34 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | CTSB | P07858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8243845 | 1.00 | CYP3A4 (0.35) | CYP3A4F2F10PRSS1ADRB3 | |
| SCHEMBL11976325 | 0.94 | CYP3A4 (0.36) | CYP3A4F2F10PRSS1ADRB3 | |
| SCHEMBL13059693 | 0.94 | CYP3A4 (0.36) | CYP3A4F2F10PRSS1ADRB3 | |
| SCHEMBL13059745 | 0.92 | CYP3A4 (0.34) | CYP3A4F2F10PRSS1ADRB3 | |
| SCHEMBL11984068 | 0.92 | CYP3A4 (0.34) | CYP3A4F2F10PRSS1ADRB3 | |
| SCHEMBL13059696 | 0.91 | ADRB3 (0.36) | CYP3A4F2F10PRSS1ADRB3 | |
| SCHEMBL8245103 | 0.91 | ADRB3 (0.36) | CYP3A4F2F10PRSS1ADRB3 | |
| SCHEMBL11984053 | 0.91 | BIRC3 (0.35) | CYP3A4F2ADRB3ADRA2BADRA2C | |
| SCHEMBL11976321 | 0.91 | CYP3A4 (0.35) | CYP3A4F2F10PRSS1ADRB3 | |
| SCHEMBL12807925 | 0.90 | CYP3A4 (0.34) | CYP3A4F2F10PRSS1ADRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7829665-B2 | Macrocyclic inhibitors of hepatitis C virus replication | INTERMUNE, INC. (US) | 2010-11-09 | — | — | US | disclosed |
| US-20070054842-A1 | Novel macrocyclic inhibitors of hepatitis C virus replication | ARRAY BIOPHARMA, INC. | 2007-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070054842-A1 | Novel macrocyclic inhibitors of hepatitis C virus replication | EIF2AK2, HAVCR2, HCCS | CYP3A4 826/4885F2 582/4885F10 2678/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.