Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 18/20 | 0.48 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.48 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.41 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.41 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10273945 | 0.88 | MAPK10 (0.45) | MAPK14MAPK10NR3C2PRKD1PRKD2 | |
| SCHEMBL13003275 | 0.86 | MAPK14 (0.47) | MAPK14MAPK10 | |
| SCHEMBL764216 | 0.78 | KCNH2 (0.41) | MAPK14MAPK10NR3C2 | |
| SCHEMBL751261 | 0.78 | MAPK14 (0.40) | MAPK14NR3C2 | |
| SCHEMBL765698 | 0.77 | MAPK8 (0.44) | MAPK14MAPK10 | |
| SCHEMBL13003269 | 0.77 | MAPK14 (0.43) | MAPK14MAPK10 | |
| SCHEMBL751331 | 0.75 | FLT3 (0.48) | MAPK14MAPK10 | |
| SCHEMBL13060367 | 0.74 | MAPK14 (0.41) | MAPK14MAPK10NR3C2 | |
| SCHEMBL764233 | 0.74 | MAPK14 (0.53) | MAPK14MAPK10NR3C2 | |
| SCHEMBL10273430 | 0.74 | MAPK14 (0.41) | MAPK14MAPK10NR3C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7846933-B2 | such as 1-(4-Fluorophenyl)-5-(pyridin-4-yl)-4-imidazolin-2-one, having excellent p38 MAP kinase inhibitory action, useful for the treatment of osteoarthritis, arthritis, ulcerative colitis, Crohn's disease, psoriasis, dermatitis, asthma, bronchitis, pneumonia, rhinitis, conjunctivitis or keratitis | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2010-12-07 | — | — | US | disclosed |
| US-20090088422-A1 | 4-IMIDAZOLIN-2-ONE COMPOUNDS | KUBO AKIRA | 2009-04-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090088422-A1 | 4-IMIDAZOLIN-2-ONE COMPOUNDS | OR10J3, NR4A3, NR3C2 | MAPK14 2186/4885MAPK10 2070/4885NR3C2 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.