Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR4 | P51679 | 5/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | EHMT2 | Q96KQ7 | 9/20 | 0.55 |
| ▸ | EHMT1 | Q9H9B1 | 4/20 | 0.55 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.51 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.51 |
| ▸ | NSD2 | O96028 | 2/20 | 0.51 |
| ▸ | KDM1A | O60341 | 1/20 | 0.49 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | STAT6 | P42226 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | KMT5A | Q9NQR1 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3775163 | 0.99 | CCR4 (0.56) | CCR4ALDH1A1SMN1; SMN2EHMT2EHMT1 | |
| SCHEMBL25250410 | 0.91 | CCR4 (0.60) | CCR4ALDH1A1SMN1; SMN2EHMT2EHMT1 | |
| SCHEMBL13015062 | 0.89 | SMN1; SMN2 (0.57) | CCR4ALDH1A1SMN1; SMN2EHMT2EHMT1 | |
| Hydrochloric Acid SCHEMBL4048123 | 0.89 | SMN1; SMN2 (0.56) | CCR4ALDH1A1SMN1; SMN2EHMT2EHMT1 | |
| Hydrochloric Acid SCHEMBL4048122 | 0.89 | SMN1; SMN2 (0.56) | CCR4ALDH1A1SMN1; SMN2EHMT2EHMT1 | |
| Hydrochloric Acid SCHEMBL3772388 | 0.89 | SMN1; SMN2 (0.56) | CCR4ALDH1A1SMN1; SMN2EHMT2EHMT1 | |
| SCHEMBL4231753 | 0.85 | EHMT2 (0.49) | EHMT2EHMT1TLR7NSD2KDM1A | |
| SCHEMBL4222888 | 0.84 | EHMT2 (0.49) | EHMT2EHMT1NSD2KDM1ARCOR1 | |
| SCHEMBL4226230 | 0.83 | EHMT2 (0.49) | EHMT2EHMT1NSD2KDM1ARCOR1 | |
| SCHEMBL4234952 | 0.83 | EHMT2 (0.51) | EHMT2EHMT1NSD2KDM1ARCOR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7855194-B2 | Pyrimidine, quinazoline, pteridine and triazine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2010-12-21 | — | — | US | disclosed |
| EP-2001867-B1 | PYRIMIDINE, QUINAZOLINE, PTERIDINE AND TRIAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2009-07-01 | — | — | EP | disclosed |
| WO-2007110340-A2 | PYRIMIDINE, QUINAZOLINE, PTERIDINE AND TRIAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-10-04 | — | — | WO | disclosed |
| US-20070225271-A1 | Pyrimidine, quinazoline, pteridine and triazine derivatives | F. HOFFMANN-LA ROCHE AG, A SWISS COMPANY (CH) | 2007-09-27 | — | — | US | disclosed |
| US-20070225271-A1 | Pyrimidine, quinazoline, pteridine and triazine derivatives | F. HOFFMANN-LA ROCHE AG, A SWISS COMPANY (CH) | 2007-09-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070225271-A1 | Pyrimidine, quinazoline, pteridine and triazine derivatives | SSTR5, SSTR3, SSTR1 | CCR4 2407/4885ALDH1A1 2891/4885SMN1; SMN2 3802/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.