SCHEMBL13063657

SCHEMBL13063657

Fc1cc(Br)ccc1Cc1cccc(-c2ncc3ccccc3n2)n1

nearest known ligand 0.38

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
PTGER1 P34995 3/20 0.35
CYP1A2 P05177 5/20 0.34
AKR1B1 P15121 1/20 0.33
GRM2 Q14416 1/20 0.33
TBXA2R P21731 3/20 0.33
CYP2C9 P11712 2/20 0.33
PTGS1 P23219 2/20 0.33
CYP2C19 P33261 2/20 0.33
PTGER3 P43115 2/20 0.33
PTGER2 P43116 2/20 0.33
BIRC5 O15392 1/20 0.33
ALOX5AP P20292 3/20 0.33
PDPK1 O15530 1/20 0.32
S1PR3 Q99500 1/20 0.32
MEN1 O00255 1/20 0.32
KMT2A Q03164 1/20 0.32
NPC1 O15118 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8777776 0.86 NPC1 (0.40) PTGER1CYP1A2S1PR3MEN1KMT2A
SCHEMBL8778228 0.82 S1PR3 (0.35) PTGER1CYP1A2TBXA2RCYP2C9PTGS1
SCHEMBL8778107 0.82 CYP1A2 (0.34) CYP1A2BIRC5
SCHEMBL8778053 0.81 CYP1A2 (0.34) PTGER1CYP1A2S1PR3NPC1
SCHEMBL8778175 0.80 PTGER1 (0.41) PTGER1CYP1A2CYP2C9CYP2C19S1PR3
SCHEMBL8778027 0.79 CYP1A2 (0.38) CYP1A2S1PR3MEN1KMT2ANPC1
SCHEMBL8778211 0.78 CYP1A2 (0.38) CYP1A2S1PR3NPC1
SCHEMBL8778306 0.78 SMN1; SMN2 (0.46) PTGER1CYP1A2CYP2C9CYP2C19MEN1
SCHEMBL8775804 0.77 NPC1 (0.40) PTGER1CYP1A2CYP2C19BIRC5S1PR3
SCHEMBL8778039 0.77 CYP1A2 (0.38) CYP1A2NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010136475-A1 SUBSTITUTED QUINAZOLINES AS FUNGICIDES SYNGENTA PARTICIPATIONS AG (CH) 2010-12-02 WO disclosed